中国针灸2026，Vol.46Issue(9)：1421-1426,6.DOI:10.13703/j.0255-2930.20250705-0001
艾灸联合健脾温肾方治疗脾肾阳虚型癌性厌食:随机对照试验
Moxibustion combined with Jianpi Wenshen formula for cancer-related anorexia of spleen-kidney yang deficiency:a randomized controlled trial
摘要
Abstract
Objective To observe the clinical efficacy of moxibustion combined with Jianpi Wenshen formula in treating cancer-related anorexia of spleen-kidney yang deficiency.Methods A total of 80 patients with cancer-related anorexia of spleen-kidney yang deficiency were randomized into an observation group and a control group,with 40 cases in each group.Jianpi Wenshen formula was given orally in the control group.On the basis of the treatment in the control group,moxibustion was applied at bilateral Zusanli(ST36),Neiguan(PC6)and Zhongwan(CV12),Guanyuan(CV4),Mingmen(GV4)in the observation group,once daily for the first 15 days,then once every other day.Both groups were treated for 4 weeks.The scores of appetite,Karnofsky performance status(KPS),nutritional risk screening 2002(NRS-2002),and patient-generated subjective global assessment(PG-SGA),as well as the serum levels of interferon-γ(IFN-γ)and C-reactive protein(CRP)were observed before and after treatment,and the clinical efficacy was evaluated after treatment in the two groups.Results After treatment,the scores of appetite,NRS-2002,PG-SGA,and the serum levels of IFN-γ and CRP were decreased compared with those before treatment in the two groups(P<0.001,P<0.05,P<0.01),and the above indexes in the observation group were lower than those in the control group(P<0.05,P<0.001);the KPS scores were increased in the two groups compared with those before treatment(P<0.001,P<0.05),and the KPS score in the observation group was higher than that in the control group(P<0.001).The marked response rate was 57.5％(23/40)in the observation group,which was higher than 30.0％(12/40)in the control group(P<0.05).Conclusion Moxibustion combined with Jianpi Wenshen formula can effectively improve appetite and overall status,and reduce the levels of IFN-γ and CRP in patients with cancer-related anorexia of spleen-kidney yang deficiency.关键词
癌性厌食/脾肾阳虚/艾灸/健脾温肾方/随机对照试验Key words
cancer-related anorexia/spleen-kidney yang deficiency/moxibustion/Jianpi Wenshen formula/randomized controlled trial(RCT)引用本文复制引用
闫民泽,何生奇,陈东晓,王玥辰,聂静,高业博,马银杰..艾灸联合健脾温肾方治疗脾肾阳虚型癌性厌食:随机对照试验[J].中国针灸,2026,46(9):1421-1426,6.基金项目
中国中医科学院望京医院院级课题项目:院WJYY2020-02 （）
