中国中西医结合急救杂志2026，Vol.33Issue(4)：397-402,6.DOI:10.3969/j.issn.1008-9691.2026.04.002
"恶血"与"微血栓":论"恶血归肝"理论与脓毒症凝血功能紊乱的相关性
Pathogenic blood and microthrombi:exploring the correlation between the theory of"pathogenic blood returning to liver"and sepsis-induced coagulopathy
摘要
Abstract
Sepsis-induced coagulopathy(SIC)is one of the critical factors contributing to the high mortality of sepsis;it is essentially characterized by the formation of systemic microthrombi mediated by immune and inflammatory processes.Currently,anticoagulant therapy faces numerous clinical challenges and has limited efficacy.The theory of"pathogenic blood returning to liver"originates from Li Dongyuan's Inventions in Medicine and emphasizes the close connection between pathogenic blood and the liver.This theory shares certain similarities with the formation of"microthrombi"in sepsis,which lead to coagulation dysfunction,in terms of their occurrence,development,and pathophysiological progression.This article systematically reviews the theory of"pathogenic blood returning to liver"and explores its intrinsic pathological connection with"microthrombi".Based on this,the core pathogenesis of SIC is characterized by"the mutual entanglement of toxins and blood stasis,the internal generation of pathogenic blood,hepatic damage,and disruption of hepatic regulatory functions".The core therapeutic principles of"clearing pathogenic blood,soothing the liver,and eliminating toxins and blood stasis"provide a theoretical framework and new perspectives for the treatment of SIC.关键词
恶血归肝/微血栓/脓毒症/肝损伤/凝血紊乱Key words
Pathogenic blood returning to liver/Microthrombi/Sepsis/Liver injury/Coagulopathy引用本文复制引用
李雅静,陈腾飞,王雪蕊,徐霄龙,杨思雯,张雨鹏,刘清泉.."恶血"与"微血栓":论"恶血归肝"理论与脓毒症凝血功能紊乱的相关性[J].中国中西医结合急救杂志,2026,33(4):397-402,6.基金项目
国家自然科学基金面上项目(82575023) General Program of the National Natural Science Foundation of China(82575023) （82575023）
