中国中西医结合急救杂志2026，Vol.33Issue(4)：419-424,6.DOI:10.3969/j.issn.1008-9691.2026.04.006
葡萄糖酸氯己定擦浴对ICU患者院内获得性感染影响的Meta分析
Effect of chlorhexidine gluconate bathing on healthcare-associated infections in intensive care unit patients:a Meta-analysis
摘要
Abstract
Objective To systematically evaluate the effects of chlorhexidine gluconate bathing on healthcare-associated infection(HAI)and clinical outcomes in intensive care unit(ICU)patients.Methods A literature search was conducted across PubMed,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure(CNKI),and Wanfang Data for randomized controlled trial(RCT)comparing chlorhexidine gluconate sponge baths with conventional sponge baths,published from January 1,2000 to December 31,2022.Two investigators independently screened studies,extracted data,and assessed study quality.Meta-analysis was used to compare the differences in the incidence of HAI,bloodstream infection,lung infection,urinary tract infection,as well as the in-hospital mortality,ICU length of stay,and total hospital length of stay between the two groups.Results Twelve RCTs involving 128 927 ICU patients were included:63 038 in the chlorhexidine gluconate bathing group and 65 889 in the control group.Compared with the control group,chlorhexidine gluconate bathing group showed significantly lower incidence of HAI[1.93%(1 219/63 038)vs.2.26%(1 490/65 889);odds ratio(OR)=0.72,95%confidence interval(95%CI)was 0.62-0.83,P<0.000 01]and bloodstream infections[1.30%(476/36 573)vs.1.54%(648/41 968);OR=0.70,95%CI was 0.62-0.79,P<0.000 01].No significant differences between groups were found in lung infection,urinary tract infection,in-hospital mortality,or total hospital length of stay(all P>0.05).ICU length of stay was slightly longer in the chlorhexidine gluconate bathing group[mean difference(MD)=0.17 days,95%CI was 0.06-0.28,P=0.004],although the absolute difference was small.Conclusions Chlorhexidine gluconate bathing reduces HAI and bloodstream infections in ICU patients.Its effects on other infection outcomes,mortality,and length of stay require confirmation in further high-quality studies.关键词
葡萄糖酸氯己定/擦浴/院内获得性感染/血流感染/重症监护病房/Meta分析Key words
Chlorhexidine gluconate/Bathing/Healthcare-associated infection/Bloodstream infection/Intensive care unit/Meta-analysis引用本文复制引用
赵加贵,钱淑媛,张瑶,王静,王伟,张学超,王乐..葡萄糖酸氯己定擦浴对ICU患者院内获得性感染影响的Meta分析[J].中国中西医结合急救杂志,2026,33(4):419-424,6.基金项目
东南大学附属中大医院护理科研基金项目(KJZC-HL-202325) Nursing Research Fund Project of Zhongda Hospital,Southeast University(KJZC-HL-202325) （KJZC-HL-202325）
