中国中西医结合影像学杂志2026，Vol.24Issue(5)：534-538,575,6.DOI:10.3969/j.issn.1672-0512.2026.05.002
阿尔茨海默病连续谱的定量磁化率成像研究
Quantitative susceptibility mapping study of Alzheimer's disease continuum
摘要
Abstract
Objective:To investigate the characteristics of brain iron-related susceptibility changes across different stages of the Alzheimer's disease(AD)continuum using quantitative susceptibility mapping(QSM)and to explore their relationship with cognitive function.Methods:This study enrolled 22 normal controls(NC group),22 individuals with subjective cognitive decline(SCD group),20 patients with mild cognitive impairment(MCI group),and 20 patients with AD(AD group).All participants underwent conventional MRI sequences,3D-T1WI,and QSM scanning.Susceptibility values were extracted from multiple brain regions,and intergroup comparisons were performed after adjusting for age.The SCD,MCI,and AD groups were combined into an AD spectrum group.Correlations between susceptibility values and age,mini-mental state examination(MMSE)scores,and Montreal Cognitive Assessment(MoCA)scores were analyzed in both the AD spectrum group and the NC group.Results:After adjusting for age,statistically significant differences in susceptibility values of the globus pallidus,caudate nucleus,and putamen were observed among the NC,SCD,MCI,and AD groups(F=26.734,10.238,32.121,respectively;all P<0.001),showing a progressive increasing trend across the four groups.Correlation analysis revealed that,in the AD spectrum group,susceptibility values in the globus pallidus,caudate nucleus,and putamen were positively correlated with age and negatively correlated with MMSE and MoCA scores.Conclusions:A progressive increase in brain iron deposition in the globus pallidus,caudate nucleus,and putamen may occur in patients with SCD,MCI,and AD.This change is associated with cognitive decline,suggesting that QSM may provide a reference for the in vivo assessment of brain iron burden.关键词
阿尔茨海默病/定量磁化率成像/铁沉积/脑网络组图谱/磁共振成像Key words
Alzheimer's disease/Quantitative susceptibility mapping/Iron deposition/Brainnetome atlas/Magnetic resonance imaging分类
医药卫生引用本文复制引用
李栋学,刘远成,姚源蓉,梁代义,王荣品..阿尔茨海默病连续谱的定量磁化率成像研究[J].中国中西医结合影像学杂志,2026,24(5):534-538,575,6.基金项目
贵州省高层次创新人才项目(黔科合平台人才-GCC[2022]041-2号). （黔科合平台人才-GCC[2022]041-2号）
