中国中西医结合影像学杂志2026，Vol.24Issue(5)：550-556,7.DOI:10.3969/j.issn.1672-0512.2026.05.005
卵圆孔未闭合并偏头痛的脑结构与血流灌注特征研究
Study on brain structural and cerebral blood perfusion characteristics in patients with patent foramen ovale-associated migraine
摘要
Abstract
Objective:To quantitatively analyze whole-brain gray matter volume alterations and cerebral blood flow(CBF)abnormalities in patients with patent foramen ovale(PFO)-associated migraine using 3D-T1WI and three-dimensional pseudo-continuous arterial spin labeling(3D-pCASL)techniques.Methods:This prospective study enrolled 28 patients with PFO-associated migraine(PFO-migraine group)and 20 healthy controls(control group).All participants underwent whole-brain 3D-T1WI and 3D-pCASL scanning.Voxel-based morphometry(VBM)was used to compare whole-brain gray matter volume and CBF between the two groups.Correlations between gray matter volume in the identified brain regions and disease duration,mini-mental state examination(MMSE)score,and headache impact test-6(HIT-6)score were analyzed.Results:Compared with the control group,the PFO-migraine group exhibited reduced gray matter volume in the bilateral anterior cingulate cortex(anterior part),bilateral superior anterior cingulate cortex,right dorsolateral superior frontal gyrus,bilateral middle cingulate cortex,right medial superior frontal gyrus,left middle temporal pole,left superior temporal pole,and left inferior temporal gyrus(all P<0.05,FWE-corrected).Increased CBF in the PFO-migraine group was predominantly observed in the right lingual gyrus,calcarine fissure,fusiform gyrus,cerebellum,inferior occipital gyrus,and precuneus(all P<0.05,FDR-corrected).With prolonged disease duration,gray matter volumes in the right dorsolateral superior frontal gyrus,right medial superior frontal gyrus,bilateral anterior cingulate cortex(anterior part),and right middle cingulate cortex were reduced(all P<0.05).Conclusions:The combination of 3D-T1WI and 3D-pCASL enables the assessment of characteristic gray matter structural changes and perfusion abnormalities in patients with PFO-associated migraine.This approach not only provides imaging evidence to elucidate the pathological mechanisms underlying gray matter atrophy in pain-modulation networks and increased visual cortical blood flow in this condition,but also offers imaging biomarkers for evaluating the efficacy of PFO closure by quantifying structural and perfusion parameters in abnormal brain regions.关键词
卵圆孔未闭/偏头痛/磁共振成像/灰质体积/脑血流量Key words
Patent foramen ovale/Migraine/Magnetic resonance imaging/Gray matter volume/Cerebral blood flow分类
医药卫生引用本文复制引用
张天资,曹磊,李京奕,董昕俣,杨海骁,雷立存..卵圆孔未闭合并偏头痛的脑结构与血流灌注特征研究[J].中国中西医结合影像学杂志,2026,24(5):550-556,7.基金项目
河北省医学科学研究课题(20260096). （20260096）
