中国中药杂志2026，Vol.51Issue(17)：4870-4877,8.DOI:10.19540/j.cnki.cjcmm.20260709.301
中药配伍形成超分子复合物的判定标准与关键表征策略
Defining and characterization of supramolecular complexes in TCM formulations
摘要
Abstract
The supramolecular perspective offers a path distinct from component analysis for understanding the material basis of TCM compatibility,shifting the research focus from co-existence of components to formation of structures.It is common that precipitates or colloidal particles appear after co-decocting of medicinal materials,while such phenomena mostly reflect phase changes in the system and are insufficient to directly identify stable and definable supramolecular complexes.Against this background,this paper systematically reviews the determination path of supramolecular structures induced by compatibility along the evidence progression logic from phenomenon particles to causal complexes,and proposes a four-level evidence system consisting of phenomenological evidence(L1),intermolecular interaction evidence(L2),evidence of structural integrity and reversibility(L3),and functional causal evidence(L4).Furthermore,this paper distills the minimum evidence set(MES)supporting the judgment of structural existence.By critically evaluating the application conditions and limitations of commonly used characterization techniques in TCM systems,this paper aims to provide a more operational and reproducible analytical framework for supramolecular research on TCM compatibility,enabling different research conclusions to be understood and compared within a unified evidence context.关键词
超分子复合物/中药配伍/自组装与聚集/证据层级/最小证据集Key words
supramolecular complexes/TCM compatibility/self-assembly and aggregation/evidence hierarchy/minimum evidence set引用本文复制引用
刘灿,谯茹,贺福元..中药配伍形成超分子复合物的判定标准与关键表征策略[J].中国中药杂志,2026,51(17):4870-4877,8.基金项目
国家自然科学基金项目(82274215) （82274215）
湖南省自然科学基金项目(2022JJ30453) （2022JJ30453）
湖南省研究生科研创新项目(CX20251190) （CX20251190）
湖南省重点研发计划项目(2022SK2014) （2022SK2014）
湖南中医药大学 2022 年度校级"揭榜挂帅"专项(2022-XJJB001) （2022-XJJB001）
