中国中药杂志2026，Vol.51Issue(17)：4886-4894,9.DOI:10.19540/j.cnki.cjcmm.20260603.302
中药水煎液中超分子聚集体的结构表征及药理机制研究进展
Research progress on structural characterization and pharmacological mechanisms of supramolecular aggregates in traditional Chinese medicine decoctions
摘要
Abstract
The investigations on pharmacodynamic material basis of traditional Chinese medicine have focused primarily on free compounds,while overlooking the complex interactions among active constituents.In recent years,it has been revealed that active constituents can self-assemble into supramolecular aggregates through non-covalent interactions during the decoction process,providing a new perspective for elucidating the pharmacodynamic material basis of traditional Chinese medicine.This study systematically reviewed the separation and purification methods and structural characterization techniques for supramolecular aggregates,explored their self-assembly mechanisms in depth,and summarized the pharmacological mechanisms.Finally,it examined the limitations of existing studies in terms of separation technologies,self-assembly mechanisms and in vivo metabolism,and proposed future research directions,with the aim of providing a reference for further in-depth research,development and utilization of supramolecular aggregates in traditional Chinese medicine.关键词
中药汤剂/超分子聚集体/自组装/结构表征Key words
traditional Chinese medicine decoction/supramolecular aggregates/self-assembly/structural characterization引用本文复制引用
刘双,董红敬,康传志,米玉璋,王晓..中药水煎液中超分子聚集体的结构表征及药理机制研究进展[J].中国中药杂志,2026,51(17):4886-4894,9.基金项目
名贵中药资源可持续利用能力建设项目(2060302) （2060302）
国家现代农业产业技术体系项目(CARS-21) （CARS-21）
山东省泰山学者工程项目(tstp20221138) （tstp20221138）
