中国中药杂志2026，Vol.51Issue(17)：4906-4916,11.DOI:10.19540/j.cnki.cjcmm.20260430.401
代谢组学在中药机制解析、质量控制和毒性研究中的应用进展
Application progress of metabonomics in mechanism analysis,quality control and toxicity studies of traditional Chinese medicine
摘要
Abstract
Traditional Chinese medicine(TCM)has a long history and well-established therapeutic efficacy.However,its complex composition,unclear active ingredients,incompletely elucidated targets and mechanisms,reliance on single-component indicators in current quality evaluation,and existing safety concerns pose challenges to quality control in terms of standardization,traceability,and scientific evidence.As an important branch of systems biology,metabolomics enables dynamic analysis of global changes in endogenous metabolites at the molecular level,providing a powerful approach to address these issues.In recent years,metabolomics has facilitated the elucidation of multi-target synergistic effects of TCM,comprehensive quality evaluation of medicinal materials,and early warning of drug-induced toxicity through the detection of metabolic pathways and biomarkers,the construction of metabolic fingerprints,and the identification of early metabolic abnormalities.Therefore,this paper systematically reviewed the application of metabolomics in mechanism analysis,quality control,and toxicity studies of TCM,aiming to provide a reference for the scientific evaluation and modernization of TCM.关键词
代谢组学/作用靶点识别及作用机制阐明/产地鉴别与地理溯源/最佳采收期分析/炮制机制/毒性机制解析Key words
metabolomics/identification of target and elucidation of mechanism of action/origin identification and geographical tracing/analysis of optimal harvest period/mechanism of processing technology/analysis of toxicity mechanism引用本文复制引用
王春霞,聂慧芳,李研,史奇,陈正君,杨扶德..代谢组学在中药机制解析、质量控制和毒性研究中的应用进展[J].中国中药杂志,2026,51(17):4906-4916,11.基金项目
国家重点研发计划项目(2018YFC1706305) （2018YFC1706305）
甘肃省重点研发计划社会发展类项目(23YFFA0069) （23YFFA0069）
甘肃省中医药研究中心开放课题(zyzx-2023-10) （zyzx-2023-10）
西北营养与环境相关疾病中医药防控协同创新中心 2025 年度开放基金课题(ZYXT-25-04) （ZYXT-25-04）
兰州市科技计划项目(2024-9-78) （2024-9-78）
甘肃省优秀研究生"创新之星"项目(2026CXZX-924) （2026CXZX-924）
