中国中药杂志2026，Vol.51Issue(18)：5170-5184,15.DOI:10.19540/j.cnki.cjcmm.20260520.501
中医药防治慢性阻塞性肺疾病的临床应用及作用机制研究进展
Research progress on clinical application and action mechanism of TCM in prevention and treatment of chronic obstructive pulmonary disease
摘要
Abstract
The pathological mechanisms of chronic obstructive pulmonary disease(COPD)are complex,and current intervention strategies are difficult to control the overall progression of the disease.Guided by the treatment principle of syndrome differentiation and treatment,TCM treats COPD based on the core pathogenesis of deficiency in origin and excess in superficiality,showing the unique advantages of multiple targets and holistic regulation.This paper systematically summarized the pathological mechanisms of COPD and the clinical and basic research progress of TCM treatment.Based on the comprehensive analysis of the etiology,pathogenesis,and modern pathological changes of COPD,this paper also summarized the clinical efficacy of TCM in the prevention and treatment of COPD and elaborated its action mechanism in depth.Clinical studies have shown that TCM compound formulas with the effects of tonifying the lungs and strengthening the spleen,nourishing the lungs and kidneys,clearing heat and dissolving phlegm,as well as external treatment methods such as acupuncture,acupoint application,and acupoint injection,can effectively improve the symptoms of cough,phlegm,shortness of breath,reduce the number of acute exacerbations,improve lung function and exercise tolerance,and significantly improve the quality of life of patients.At the level of basic research,a variety of active components such as flavonoids,saponins,and polysaccharides contained in TCM,as well as compound formulas play a protective role by intervening with multiple signaling pathways and targets,including nuclear factor-κB(NF-κB)/NOD-like receptor family pyrin domain-containing 3(NLRP3),transforming growth factor-β(TGF-β)/Smad,nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1),and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt),thereby exerting multi-pathway protective effects in inhibiting inflammatory responses,alleviating oxidative stress,improving airway remodeling,regulating protease-antiprotease imbalance,and modulating programmed cell death.In addition,this paper pointed out the shortcomings in the current research field,aiming to provide new theoretical bases and research ideas for the comprehensive prevention and treatment of COPD and the modernized research of TCM.关键词
慢性阻塞性肺疾病/中医药/临床应用/基础研究/研究进展Key words
chronic obstructive pulmonary disease/TCM/clinical application/basic research/research progress引用本文复制引用
孟青婷,朱虹宇,胡嘉怡,杨程,童佳兵,李泽庚,杨勤军..中医药防治慢性阻塞性肺疾病的临床应用及作用机制研究进展[J].中国中药杂志,2026,51(18):5170-5184,15.基金项目
国家自然科学基金区域创新重点项目(U20A20398) （U20A20398）
国家自然科学基金面上项目(82374399) （82374399）
2024年度高等学校科研计划项目(2024AH051047) （2024AH051047）
安徽省中医药传承创新科研项目(2024CCCX077) （2024CCCX077）
