中华骨质疏松和骨矿盐疾病杂志2026，Vol.19Issue(4)：483-489,7.DOI:10.3969/j.issn.1674-2591.2026.04.007
炎症细胞因子与甲状旁腺激素因果关联的孟德尔随机化研究
Mendelian randomization study on the causal association between serum inflammatory cytokines and parathyroid hormone
摘要
Abstract
Objective To identify the causal associations between serum inflammatory cytokines and parathy-roid hormone(PTH)levels using bidirectional Mendelian randomization(MR)analysis.Methods A bidirectional MR design was employed,utilizing single nucleotide polymorphisms(SNPs)as instrumental variables to assess the causal effects of serum inflammatory cytokines on PTH levels and vice versa.Publicly available genotype data were ana-lyzed using inverse-variance weighted(IVW),MR Egger,simple mode,enhanced mode and weighted median meth-ods.Sensitivity analyses were conducted to evaluate the reliability of the results.Results Forward MR analysis showed a significant negative association between osteoprotegerin(OPG)and PTH levels(OR=0.426,95%CI:0.201-0.905,P=0.026).Reverse MR analysis revealed a significant negative association between PTH and tumor necrosis factor ligand superfamily member 14(TNFSF14)levels(OR=0.963,95%CI:0.933-0.995,P=0.022),and a significant positive association between PTH and interleukin-17C(IL-17C)levels(OR=1.039,95%CI:1.004-1.075,P=0.031).No heterogeneity or pleiotropy was detected in sensitivity analyses.Conclusion There is a nega-tive correlation between OPG and PTH,while the level of PTH is negatively correlated with the level of TNFSF14 and positively correlated with IL-17C.关键词
甲状旁腺激素/炎症细胞因子/因果关联/生理机制/骨质疏松症/骨代谢/骨保护素Key words
parathyroid hormone/inflammatory cytokines/causal association/physiological mechanism/osteo-porosis/bone metabolism/osteoprotegerin分类
医药卫生引用本文复制引用
高增杰,游正琴,黄华,覃裕,张望明..炎症细胞因子与甲状旁腺激素因果关联的孟德尔随机化研究[J].中华骨质疏松和骨矿盐疾病杂志,2026,19(4):483-489,7.基金项目
贵州省卫生健康委科学技术基金(gzwkj2025-364) （gzwkj2025-364）
贵州省中医药、民族医药科学技术研究专项(QZYY-2025-023) （QZYY-2025-023）
