中国畜禽种业2026，Vol.22Issue(9)：95-102,8.DOI:10.19543/j.cnki.1673-4556.20260803.001
DLK1-DIO3印记簇在家畜胚胎发育中的研究进展
Research progress on the DLK1-DIO3 imprinted cluster in livestock embryonic development
摘要
Abstract
Imprinted genes are regulated through epigenetic mechanisms and are expressed in a parent-of-origin-specific manner.These genes are often clustered together and serve as crucial regulators in normal embryonic development and individual health.The DLK1-DIO3 imprinted cluster is a key regulatory region influencing livestock embryonic development and placental formation.The imprinting status of this cluster is primarily determined by the parent-of-origin-specific methylation of the core imprinting control region,IG-DMR(Imprinting Gene Differentially Methylated Region),which governs the overall parent-specific expression pattern of the cluster.GTL2-DMR(GTL2-Differentially Methylated Region),as a secondary DMR,maintains the stable expression of the maternal transcripts.This review summarizes the composition,imprinting regulation,and functional roles of this cluster,with a particular focus on the regulatory functions of the paternal genes DLK1,RTL1,DIO3,and the maternal gene GTL2 in placental angiogenesis,muscle growth,neural differentiation,and energy metabolism.The case of the Callipyge(CLPG)sheep,exhibiting a polar overdominant inheritance pattern,highlights the potential of manipulating this gene cluster to improve meat production traits and reproductive performance in livestock,so as to provide theoretical reference for improving the production performance and reproductive efficiency of livestock.关键词
基因组印记/DLK1-DIO3/家畜/胚胎发育Key words
Genomic imprinting/DLK1-DIO3/Livestock/Embryonic development分类
农业科技引用本文复制引用
鞠思含,朱梁,赵温倩,刘忠华,翁晓刚..DLK1-DIO3印记簇在家畜胚胎发育中的研究进展[J].中国畜禽种业,2026,22(9):95-102,8.基金项目
国家重点研发项目(2022YFD1302203). （2022YFD1302203）
