转化医学杂志2026，Vol.15Issue(10)：1637-1641,5.DOI:10.3639/j.issn.2095-3097.2026.10.001
常规超声联合实时组织弹性成像在肉芽肿性小叶性乳腺炎与浸润性小叶癌中的鉴别诊断价值
Value of Conventional Ultrasound Combined with Real-Time Tissue Elastography in the Differential Diagnosis of Granulomatous Lobular Mastitis and Invasive Lobular Carcinoma
摘要
Abstract
Objective To explore the value of conventional ultrasound combined with real-time tissue elastography in the differential diagnosis of granulomatous lobular mastitis(GLM)and invasive lobular carcinoma(ILC)of the breast.Methods A retrospective analysis was conducted on 145 female patients with GLM(n=145)diagnosed at the First Affiliated Hospital of Nanjing Medical University from March 2020 to August 2023 as the GLM group.Another 145 female patients with ILC during the same period were randomly selected as the control group.The clinical data,conventional ultrasound morphology,blood flow characteristics,and real-time tissue elastography scores were compared between the two groups,and the characteristic imaging findings of the two types of lesions were summarized.Results The onset age of the GLM group was lower than that of the ILC group,the distance from the lesion to the nipple was shorter than that of the ILC group,the maximum diameter of the lesion was longer than that of the ILC group,and the proportions of patients presenting with inflammatory manifestations,skin involvement,and sinus tract formation were higher than those of the ILC group(all P<0.05).Regarding ultrasound features,the GLM group showed higher proportions of multifocal lesions,fluid echoes,posterior acoustic enhancement,heterogeneous internal echoes,enhanced echogenicity or edema in surrounding tissues,marginal blood flow,resistance index(RI)≤0.7,BI-RADS category 3-4A,and an elasticity score of 3 than the ILC group.Conversely,the proportions of patients with spiculated or crab-claw-like margins,irregular lesions,and calcifications in the GLM group were lower than those in the ILC group(all P<0.05).Conclusion Compared with ILC patients,patients with GLM have an earlier onset age and are more prone to clinical signs like redness,swelling,heat,pain,skin involvement,and sinus tract formation.On ultrasound,GLM lesions often exhibit fluid echoes,low-resistance marginal blood flow,and softer tissue consistency.GLM and ILC differ in their clinical manifestations,conventional ultrasonographic features,and real-time tissue elastography findings.Comprehensive assessment of these features may facilitate the differential diagnosis between the two diseases.关键词
乳腺/肉芽肿性小叶性乳腺炎/浸润性小叶癌/弹性成像/超声检查Key words
breast/granulomatous lobular mastitis/invasive lobular carcinoma/elastography/ultrasonography引用本文复制引用
巩海燕,胡菊萍,徐超丽,董叶,查海玲,栗翠英,宗晴晴..常规超声联合实时组织弹性成像在肉芽肿性小叶性乳腺炎与浸润性小叶癌中的鉴别诊断价值[J].转化医学杂志,2026,15(10):1637-1641,5.基金项目
国家自然科学基金项目(82302216) （82302216）
