转化医学杂志2026，Vol.15Issue(10)：1652-1657,6.DOI:10.3639/j.issn.2095-3097.2026.10.004
基于胃肠超声助显剂辅助下腹部超声成像预测胰十二指肠切除术后并发临床胃排空延迟的前瞻性研究
A Prospective Study on Predicting Clinical Relevant Delayed Gastric Emptying After Pancreaticoduodenectomy by Abdominal Ultrasonography Assisted by Gastrointestinal Ultrasound Contrast Agent
摘要
Abstract
Objective To quantitatively evaluate the preoperative gastric emptying rate of patients via abdominal ultrasonography assisted by gastrointestinal ultrasound contrast agent,and explore its potential clinical value in predicting delayed gastric emptying(DGE)after pancreaticoduodenectomy.Methods A total of 107 patients who underwent pancreaticoduodenectomy at the Department of Hepatobiliary and Pancreatic Surgery,the First Medical Center of the Chinese PLA General Hospital from January 2024 to May 2025 were prospectively enrolled.All patients were divided into the DGE-positive group(n=14)and DGE-negative group(n=93)according to the occurrence of postoperative DGE.Within 1 week before surgery,abdominal ultrasonography assisted by gastrointestinal ultrasound contrast agent was performed to measure the gastric antral area at fasting state,immediately after contrast agent administration,and at 30 minutes and 60 minutes after administration.The 30-minute and 60-minute gastric emptying rate(GER)values were calculated subsequently.Multivariate logistic regression analysis was used to identify the risk factors for DGE after pancreaticoduodenectomy.ROC curve analysis was applied to evaluate the diagnostic value of the 60-minute GER for predicting postoperative DGE.Results The 60-minute GER in the DGE-positive group(40.79±19.05)％was significantly lower than that in the DGE-negative group(55.03±19.11)％,and the postoperative hospital stay was longer in the DGE-positive group(P<0.05).Multivariate logistic regression analysis showed that preoperative serum albumin and preoperative 60-minute GER were independent protective factors against DGE after pancreaticoduodenectomy(OR=0.136,95％CI:0.029-0.643,P=0.011;OR=0.009,95％CI:0.001-0.258,P=0.006).ROC curve analysis indicated that the optimal cut-off value of the 60-minute GER for predicting postoperative DGE was 0.505,with an AUC of 0.714,a sensitivity of 78.63％and a specificity of 61.34％.Conclusion The gastric emptying rate quantitatively measured by abdominal ultrasonography assisted by gastrointestinal ultrasound contrast agent before surgery is an effective and independent indicator for predicting DGE after pancreaticoduodenectomy.This non-invasive and convenient method for preoperative gastric motility function assessment provides new objective evidence for preoperative risk stratification and individualized perioperative management,and has potential clinical application value.关键词
腹部超声/胃肠超声助显剂/胰十二指肠切除术/临床相关术后胃排空延迟/预测Key words
abdominal ultrasonography/gastrointestinal ultrasound contrast agent/pancreaticoduodenectomy/clinically relevant postoperative delayed gastric emptying/prediction引用本文复制引用
贠婷,王冠宇,李昶田,鲁媛媛,祝建勇,闫瑞芳..基于胃肠超声助显剂辅助下腹部超声成像预测胰十二指肠切除术后并发临床胃排空延迟的前瞻性研究[J].转化医学杂志,2026,15(10):1652-1657,6.基金项目
河南省高等学校重点科研项目(24B320017) （24B320017）
