转化医学杂志2026，Vol.15Issue(10)：1671-1675,5.DOI:10.3639/j.issn.2095-3097.2026.10.007
TG/HDL-C联合β2-微球蛋白对血液透析患者腹主动脉钙化的预测价值
Predictive Value of TG/HDL-C Combined with β2-Microglobulin for Abdominal Aortic Calcification in Hemodialysis Patients
摘要
Abstract
Objective To investigate the predictive value of triglyceride to high-density lipoprotein cholesterol ratio(TG/HDL-C)combined with β2-microglobulin(β2-MG)for abdominal aortic calcification in hemodialysis patients.Methods A total of 182 hemodialysis patients admitted to the People's Hospital of Qiandongnan Miao and Dong Autonomous Prefecture,from January 2024 to June 2025 were retrospectively enrolled.According to the presence or absence of abdominal aortic calcification,they were divided into the calcification group(n=63)and non-calcification group(n=119).Clinical data of the patients and pre-dialysis serum levels of TG,HDL-C and β2-MG were collected,and the TG/HDL-C ratio was calculated.ROC curves were used to evaluate the value of TG/HDL-C,β2-MG and their combination in predicting abdominal aortic calcification in hemodialysis patients.Stepwise multivariate logistic regression analysis was performed to analyze the influencing factors of abdominal aortic calcification in hemodialysis patients.Results The levels of TG/HDL-C and serum β2-MG in the calcification group were significantly higher than those in the non-calcification group(P<0.001).ROC curve analysis showed that the AUC of TG/HDL-C and β2-MG for predicting abdominal aortic calcification in hemodialysis patients were 0.803 and 0.784,respectively,and the AUC of the combined prediction was 0.907.The AUC of combined prediction was significantly better than that of single indicator(P<0.001).The age,dialysis vintage,serum calcium,serum phosphorus and intact parathyroid hormone levels in the calcification group were higher than those in the non-calcification group,and the hemoglobin level was lower than that in the non-calcification group(P<0.05).Stepwise multivariate logistic regression analysis showed that advanced age,prolonged dialysis vintage,elevated TG/HDL-C and increased β2-MG levels were independent risk factors for abdominal aortic calcification in hemodialysis patients(OR=2.173,95％CI:1.228-3.843,P=0.008;OR=2.563,95％CI:1.361-4.826,P=0.004;OR=3.297,95％CI:1.817-5.983,P<0.001;OR=2.883,95％CI:1.672-4.972,P<0.001).Conclusion Elevated levels of TG/HDL-C and β2-MG are closely correlated with abdominal aortic calcification in hemodialysis patients,and the combination of the two indicators has high predictive value for abdominal aortic calcification in hemodialysis patients.关键词
三酰甘油/高密度脂蛋白胆固醇比值/β2-微球蛋白/血液透析/血管钙化/预测价值Key words
triglyceride to high-density lipoprotein cholesterol ratio/β2-microglobulin/hemodialysis/vascular calcification/predictive value引用本文复制引用
马国英,谭孝琴,鹿岑丹,伍铭艳,向宏林,王静..TG/HDL-C联合β2-微球蛋白对血液透析患者腹主动脉钙化的预测价值[J].转化医学杂志,2026,15(10):1671-1675,5.基金项目
贵州省卫生健康委员会临床重点专科建设"攀峰计划"项目(GZWJWPF2025027) （GZWJWPF2025027）
2026年度贵州省卫生健康委员会科学技术基金立项项目(gzwkj2026-018) （gzwkj2026-018）
