转化医学杂志2026，Vol.15Issue(10)：1681-1685,5.DOI:10.3639/j.issn.2095-3097.2026.10.009
短肽-整蛋白序贯肠内营养支持在慢性阻塞性肺疾病急性发作患者中的应用效果
Application Effect of Short Peptide-Intact Protein Sequential Enteral Nutrition Support in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To explore the application effect of short peptide-intact protein sequential enteral nutrition support regimen in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 404 patients with AECOPD admitted to Linfen Central Hospital from January 2024 to December 2025 were selected as research subjects,and divided into the sequential group(n=202)and the control group(n=202)using the random number table method.The control group was given conventional intact protein enteral nutrition preparation;The sequential group was given short peptide enteral nutrition preparation on days 1 to 4,and switched to intact protein enteral nutrition preparation from day 5 onwards.The nutritional metabolism indexes[serum albumin(Alb),transferrin(TRF),prealbumin(PA)],respiratory and pulmonary function indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2),forced expiratory volume in one second(FEV1),the percentage of FEV1 to the predicted value(FEV1％pred)],intestinal barrier function indexes[serum diamine oxidase(DAO),D-lactic acid],clinical prognosis indexes and enteral nutrition-related adverse reactions were compared between the two groups before and after treatment.Results On the 7th and 14th days of treatment,the levels of Alb,TRF and PA were increased in both groups(all P<0.05),and the levels in the sequential group were all higher than those in the control group(all P<0.05).On the 14th day of treatment,the levels of PaO2,FEV1 and FEV1％pred were increased in both groups(all P<0.05),and were higher in the sequential group than in the control group(all P<0.05);the levels of PaCO2,DAO and D-lactic acid were decreased in both groups(all P<0.05),and were lower in the sequential group than in the control group(all P<0.05).The duration of mechanical ventilation,length of ICU stay and total length of hospital stay in the sequential group were all shorter than those in the control group(all P<0.05),and the incidence of enteral nutrition-related adverse reactions was lower than that in the control group 26.24％vs 36.14％,(P<0.05).Conclusion Short peptide-intact protein sequential enteral nutrition support can improve the nutritional status and intestinal barrier function of patients with AECOPD,promote the recovery of respiratory function,shorten the rehabilitation cycle and reduce the incidence of adverse reactions.关键词
慢性阻塞性肺疾病/急性加重/短肽型肠内营养剂/整蛋白型肠内营养剂/肠内营养支持Key words
chronic obstructive pulmonary disease/acute exacerbation/short peptide enteral nutrition preparation/intact protein enteral nutrition preparation/enteral nutrition support引用本文复制引用
韩彩芳,段冬仙,李静,耿萌,张智霞..短肽-整蛋白序贯肠内营养支持在慢性阻塞性肺疾病急性发作患者中的应用效果[J].转化医学杂志,2026,15(10):1681-1685,5.基金项目
山西省卫生健康委员会科研课题计划项目(2021156) （2021156）
