中兽医医药杂志2026，Vol.45Issue(5)：1-8,8.DOI:10.13823/j.cnki.jtcvm.2026.045
AHP-熵权法与总评归一法对比优化黄白健脾口服液提取工艺
Comparison of AHP-entropy weight method and overall evaluation normalization for optimizing the extraction process of Huangbai Jianpi oral liquid
摘要
Abstract
The objective was to optimize the water extraction process of Huangbai Jianpi oral liquid,providing an experimental basis for its standardized manufacturing and quality control.Using puerarin and berberine hydrochloride content,as well as extract yield,as evaluation criteria,and building upon single-factor experiments,this study employed L9(34)orthogonal experimental design with water addition multiple(A),extraction time(B),and extraction cycles(C)as influencing factors.The orthogonal experimental results were comprehensively evaluated and analyzed by both the AHP-entropy weight method and the overall normalization method.The optimal extraction process parameters were identified accordingly,and validation experiments were subsequently conducted.Single-factor experiments showed that the contents of puerarin and berberine hydrochloride initially increased and then decreased with increasing water addition multiple,extraction time,and extraction cycles.The results of the orthogonal experiment showed that the two methods yielded consistent rankings of factor influence(extraction cycles＞extraction time＞water addition multiple);however,the optimal processes differed.AHP-entropy weight method identified the optimal process parameters as A2B2C3(10-fold water,extracted three cycles,1.0 h each time),whereas the overall evaluation normalization identified A2B3C3(10-fold water,extracted three cycles,1.5 h each time).Validation experiments showed that under the A2B3C3 conditions,the puerarin content(5.134 mg/mL),berberine hydrochloride content(0.388 mg/mL),and extract yield(28.90%)were higher than those under the A2B2C3 conditions,and the process exhibited good repeatability(RSD＜3%).The overall evaluation normalization exhibits stronger objectivity and better agreement with the validation results.Accordingly,the optimal water extraction process for Huangbai Jianpi oral liquid is determined as adding 10-fold water and extracting three cycles,each cycle lasting 1.5 h.This process results in more stable contents of puerarin,berberine hydrochloride and extract yield,and can be used as the basis for industrial manufacturing of Huangbai Jianpi oral liquid.关键词
黄白健脾口服液/提取工艺参数/AHP-熵权法/总评归一法Key words
Huangbai Jianpi oral liquid/extraction process parameter/AHP-entropy weight method/overall evaluation normalization分类
农业科技引用本文复制引用
黄莉萍,王磊,张康,张景艳,郭志廷,路晓荣,雷成威,李建喜..AHP-熵权法与总评归一法对比优化黄白健脾口服液提取工艺[J].中兽医医药杂志,2026,45(5):1-8,8.基金项目
国家现代农业(奶牛)产业技术体系(CARS-36) （奶牛）
甘肃省科技重大专项计划项目(24ZDNA001) （24ZDNA001）
中国农业科学院科技创新工程中兽医与临床团队建设项目(25-LZIHPS-06) （25-LZIHPS-06）
