中兽医医药杂志2026，Vol.45Issue(5)：26-37,12.DOI:10.13823/j.cnki.jtcvm.2026.046
党参荆芥颗粒制备工艺优化
Optimization of the preparation process of Dangshen Jingjie granules
摘要
Abstract
To address the drawbacks of traditional water-decocted preparations of Dangshen Jingjie compound,such as inconvenient storage and transportation,as well as difficulty in precise control of administered dosage.Based on quality by design(QbD),the Box-Behnken response surface methodology was adopted to optimize the extraction process of Dangshen Jingjie extract in this experiment.Single-factor tests were performed to screen single and combined excipients including medicinal dextrin,soluble starch,sucrose and microcrystalline cellulose.The D-optimal design response surface methodology was applied to optimize the granule forming process.The optimal extraction process was determined as extraction time of 80 min,liquid-to-material ratio of 10∶1(mL∶g),and 2 extraction cycles.The optimal excipient combination was medicinal dextrin and microcrystalline cellulose.The optimal forming process was set as follows:relative density of extract 1.13,extract-to-excipient ratio 1.16∶1,dextrin-to-microcrystalline cellulose ratio 3.57∶1,drying temperature 51.6℃,drying time 7.1 h.The preparation process of Dangshen Jingjie granules optimized in this study is scientific and reasonable with simple operations,which is suitable for industrial mass production.The prepared granules feature stable quality and convenient administration,and can provide reliable experimental basis and technical references for new drug research and development,clinical application and large-scale production of this compound granule.关键词
党参荆芥颗粒/质量源于设计/响应面法/综合评价Key words
Dangshen Jingjie granules/quality by design/response surface methodology/comprehensive evaluation分类
农业科技引用本文复制引用
肖开颜,仇正英,何晓蓓,朱永丽,王贵波..党参荆芥颗粒制备工艺优化[J].中兽医医药杂志,2026,45(5):26-37,12.基金项目
"十四五"国家重点研发计划项目(2022YFD1602203) （2022YFD1602203）
甘肃省科技计划项目(21CX6NA126) （21CX6NA126）
中国农业科学院科技创新工程(CAAS-ASTIP-2015-LIHPS-06) （CAAS-ASTIP-2015-LIHPS-06）
中国农业科学院高产高效技术集成与示范推广项目(ZHJGCGX2025018) （ZHJGCGX2025018）
