中兽医医药杂志2026，Vol.45Issue(5)：38-44,7.DOI:10.13823/j.cnki.jtcvm.2026.042
乙酰氨基阿维菌素在不同动物体内的药代动力学研究进展
Review on pharmacokinetics of eprinomectin in different animals species
摘要
Abstract
Eprinomectin(EPR)is a broadspectrum macrolide antiparasitic drug.Because of its high efficiency and low residue,it is widely used in parasitic control of ruminants such as cattle and sheep,as well as other species of animals such as horses,camels,alpacas,reindeer,giraffes,rabbits and other animals.The pharmacokinetic study of EPR in cattle is more detailed and has been systematically reviewed.However,in recent years,the pharmacokinetic study of EPR in other animals has been increasing,but there is no systematic summary and comparison.In this paper,the research progress of pharmacokinetics of EPR in other animals was reviewed,and the effects of different administration routes and dosage forms such as pouring,subcutaneous injection and oral administration on key pharmacokinetic parameters(Cmax,Tmax,AUC,t1/2,MRT,etc.)were compared.The results showed that the pharmacokinetics of EPR in different species of animals was affected by animal species,physiological status(such as lactation period,castration),dosage and route of administration,and there were obvious species differences.This paper provided a theoretical basis and practical guidance for further optimizing the precise medication and crossspecies application of EPR.关键词
乙酰氨基阿维菌素/药代动力学/不同动物/羊/驴/鹿/兔Key words
eprinomectin/pharmacokinetics/different animals/sheep/donkey/deer/rabbit分类
农业科技引用本文复制引用
张贺超,白莉霞,葛闻博,刘希望,杨亚军,李剑勇..乙酰氨基阿维菌素在不同动物体内的药代动力学研究进展[J].中兽医医药杂志,2026,45(5):38-44,7.基金项目
甘肃省重点研发计划-农业类项目(23YFNA0013) （23YFNA0013）
甘肃省研产融合科技攻关赋能计划-农业领域(25FNNA001) （25FNNA001）
