植物保护学报2026，Vol.53Issue(4)：859-868,10.DOI:10.13802/j.cnki.zwbhxb.2026.2026005
昆虫γ-氨基丁酸转运蛋白的研究进展
Research progress on γ-aminobutyric acid transporters in insect
摘要
Abstract
Gamma-aminobutyric acid(GABA)is the primary inhibitory neurotransmitter in the insect nervous system,mediating inhibitory synaptic transmission through binding to GABA receptors.GABA transporters(GATs)play essential roles in regulating GABAergic neurotransmission.In insects,GATs include plasma membrane GABA transporters(pmGATs)and vesicular GABA transporters(vGATs),of which are widely distributed in the central nervous system.pmGATs are located to the plasma mem-brane and are responsible for the reuptake of GABA from the synaptic cleft,whereas vGATs are located to synaptic vesicle membranes within presynaptic terminals and mediate the uptake of cytoplasmic GABA into synaptic vesicles for subsequent release.This review summarizes recent advances in the study of insect pmGATs and vGATs,with emphasis on their molecular structures,phylogenetic relation-ships,spatial distribution,spatiotemporal expression patterns,and physiological functions.It aims to provide a reference for understanding the molecular basis of GABAergic neurotransmission and for identifying potential molecular targets for the development of novel pest control strategies.关键词
昆虫/γ-氨基丁酸/转运蛋白/质膜GAT/囊泡GATKey words
insect/γ-aminobutyric acid/transporter/plasma membrane GABA transporter/vesicular GABA transporter引用本文复制引用
张一弛,朱彬洲,鲍建,汪莹,唐涛,赵春青..昆虫γ-氨基丁酸转运蛋白的研究进展[J].植物保护学报,2026,53(4):859-868,10.基金项目
西藏自治区科技计划项目(XZ202601ZY0034),2024年中国科协青年人才托举工程博士生专项计划项目(STID156-O-210-0000392-3),江苏省研究生科研与实践创新计划项目(KYCX25_0984) （XZ202601ZY0034）
