中国现代医生2026，Vol.64Issue(23)：5-9,18,6.DOI:10.3969/j.issn.1673-9701.2026.23.002
免疫细胞、代谢产物与骨关节炎的因果关联的孟德尔随机化研究
Mendelian randomization study on the causal relationship between immune cells,metabolites,and osteoarthritis
摘要
Abstract
Objective To investigate the causal associations between immune cells,metabolites and osteoarthritis(OA)by mediation Mendelian randomization(MMR),and to provide new scientific insights for the study of OA pathogenesis and clinical treatment.Methods Based on the publicly available Genome-Wide Association Study database,a comprehensive analysis was conducted involving 731 types of immune cells 1400 metabolites,and OA-related genetic data.A systematic evaluation of causal relationships among these three factors was performed using two-sample methods and MMR approaches.Results Mendelian randomization analysis results indicated a clear causal relationship between HLA DR expression on CD14+CD16+monocytes,CD8 expression on TD CD8br T cells,CD4+activated Treg cells,and OA,as well as significant causal links among 20 metabolites and OA.MMR revealed that N-acetylmethionine mediates the reduction of OA risk through CD8 expression on TD CD8br T cells,while 4-hydroxychlorophenol and the glycine/serine ratio both mediate this risk reduction via CD4+activated Treg cells.(S)-3-hydroxybutyryl carnitine mediates OA risk reduction through HLA DR CD14+CD16+monocytes,with no heterogeneity or level heterogeneity observed during the study(P>0.05).Conclusion This study employed the MMR method to demonstrate that metabolites can mediate the influence of immune cells on the pathogenesis of OA.关键词
中介孟德尔随机化分析/骨关节炎/免疫细胞/逆方差加权法Key words
Mendelian randomization mediation analysis/Osteoarthritis/Immunological cell/Antidivariance weighting method分类
医药卫生引用本文复制引用
王栋梁,段戡,梅其杰,袁长深,郭锦荣,郑海军,曾超,徐文飞..免疫细胞、代谢产物与骨关节炎的因果关联的孟德尔随机化研究[J].中国现代医生,2026,64(23):5-9,18,6.基金项目
国家自然科学基金项目(82060875,82160912) （82060875,82160912）
2023 年广西中医药大学青年科学基金项目(2022QN012) （2022QN012）
2023年广西中医药大学第一附属医院青年科学基金项目(院字[2023]29号) （院字[2023]29号）
