中西医结合肝病杂志2026，Vol.36Issue(8)：945-950,6.DOI:10.3969/j.issn.1005-0264.2026.008.001
非酒精性脂肪性肝病患者血清支链氨基酸水平与肌肉减少症的相关性
Correlation between serum branched-chain amino acid levels and sarcopenia in pa-tients with nonalcoholic fatty liver disease
摘要
Abstract
Objective:To explore the correlation between serum branched-chain amino acid levels and sarcopenia in patients with Non-alcoholic fatty liver disease(NAFLD).Methods:A total of 336 patients with NAFLD admitted to our hospital from February 2019 to February 2023 were collected,including 177 males and 159 females,aged 34 to 76 years,with an average age of(54.32±7.74)years.The data of patients with different levels of branched-chain amino acids(BCAA)were divided into 4-quartile array from low to high,and the independent correlation between the level of BCAA and multivariate logistic regression analysis was performed to determine the independent correlation between the level of BCAA and the risk of developing sarcopenia in NAFLD patients.The sensitivity was tested by correlation E-value method,and LOWESS analysis was performed on the level of BCAA and related indicators of sarcopenia with the help of TIMER database.The relationship between serum BCAA level,lipid metabolism and sarcopenia was analyzed by interaction analysis.The dose-response relationship between BCAA level and sarcopenia in NAFLD patients was analyzed by restricted cubic spline analysis.Results:The results of single factor analysis showed that with the increase of BCAA level,the proportion of occasional drinking,the proportion of sarcosis,ALT,TBil,γ-GT and UA gradually increased,and the difference was statistically significant(P＜0.05).Multivariate Logistic analysis showed that after adjusting for other factors,high levels of BCAA were still independently correlated with the risk of developing sarcopenia,and higher levels of BCAA were more correlated with the risk of developing sarcopenia.In the sensitivity analysis,the E value was 2.137 and the lower limit of 95％CI was 1.82.LOWESS analysis showed that the level of BCAA was negatively correlated with SMI,grip strength and walking speed.In Q4(branched-chain amino acid level＞480.1 μmol/L)group,when the TC level was＞5.18 mmol/L,the TG level was＞1.70 mmol/L,the LDL-C level was＞3.37 mmol/L,and the HDL-C level was 1.26 mmol/L,The proportion of NAFLD patients with sarcopenia was the highest(P＜0.05).The results of interaction analysis showed that there was an interaction between the levels of lipid metabolism indicators TC,TG,LDL-C,HDL-C and the levels of BCAA on the incidence of sarcopenia in additive model and multiplicative model,showing a synergistic effect.The results of restricted cubic spline showed that the risk of sarcopenia increased with the increase of BCAA levels.Conclusion:The level of BCAA in NAFLD patients is associated with the risk of sarcopenia,and high levels of BCAA increase the risk of sarcopenia in NAFLD patients.关键词
非酒精性脂肪肝/支链氨基酸水平/肌肉减少症/相关性Key words
nonalcoholic fatty liver/branched-chain amino acid level/sarcopenia/correlation分类
医药卫生引用本文复制引用
郑锡凤,毕建华,徐俊马,周鑫..非酒精性脂肪性肝病患者血清支链氨基酸水平与肌肉减少症的相关性[J].中西医结合肝病杂志,2026,36(8):945-950,6.基金项目
2023年常州市基础研究计划(应用基础研究)项目(No.CJ20230003),2022年度江苏医药职业学院校外教学基地科研发展专项课题(No.20229122),江苏省卫健委老年健康科研项目(No.LR2021044) （应用基础研究）
