中西医结合肝病杂志2026，Vol.36Issue(8)：951-956,6.DOI:10.3969/j.issn.1005-0264.2026.008.002
基于因子分析和聚类分析的儿童代谢相关脂肪性肝病中医证候研究
Study on traditional Chinese medicine syndrome distribution in children with metabolic dysfunction-associated fatty liver disease based on factor analysis and cluster analysis
摘要
Abstract
Objective:To investigate the distribution patterns of Traditional Chinese Medicine(TCM)syndromes in children with metabolic dysfunction-associated fatty liver disease(MAFLD)based on factor analysis and cluster analysis,providing a reference for the clinical syndrome differentiation of this disease.Methods:A cross-sectional study was conducted,enrolling 361 children with MAFLD who attended the TCM outpatient clinic of Beijing Children's Hospital,Capital Medical University,between January 2023 and March 2025.Data on general information,symptoms,signs,tongue and pulse manifestations(the four diagnostic methods),and relevant biochemical indicators were collected.Principal component factor analysis was performed using SPSS 27.0,followed by K-means clustering to identify TCM syndrome distributions.The correlations between biochemical indicators and different syndrome types were compared.Results:Factor analysis extracted six common factors with eigenvalues＞1,whose cumulative contribution rate was 65.52％.Cluster analysis identified five syndrome types:syndrome of accumulated dampness-heat,syndrome of stomach heat-spleen deficiency,syndrome of stagnation of liver qi and spleen deficiency,syndrome of phlegm intermingled and blood stasis,and syndrome of spleen-kidney deficiency,accounting for 32.13％,22.99％,19.67％,15.24％,and 9.97％,respectively.Gender showed a significant difference among the different syndrome types(P＜0.05).The levels of aspartate aminotransferase and alanine aminotransferase in the syndrome of accumulated dampness-heat were significantly higher than those in other syndrome types(P＜0.05).The elevation of gamma-glutamyl transferase was most pronounced in the syndrome of phlegm intermingled and blood stasis(P＜0.05).Conclusion:The TCM syndromes of accumulated dampness-heat and stomach heat-spleen deficiency are relatively common in children with MAFLD.The gender distribution differs significantly among the syndrome types,and the liver enzyme profiles exhibit syndrome-specific patterns,providing auxiliary evidence for the clinical diagnosis and treatment of pediatric MAFLD.关键词
代谢相关脂肪性肝病/因子分析/聚类分析/证候特点Key words
metabolic dysfunction-associated fatty liver disease/factor analysis/cluster analysis/syndrome characteristics分类
医药卫生引用本文复制引用
王玲,纪丰烨,张晓辉,陈梦瑶,何强..基于因子分析和聚类分析的儿童代谢相关脂肪性肝病中医证候研究[J].中西医结合肝病杂志,2026,36(8):951-956,6.基金项目
首都卫生发展科研专项(No.首发2024-2-2095) （No.首发2024-2-2095）
