中西医结合肝病杂志2026，Vol.36Issue(8)：982-986,5.DOI:10.3969/j.issn.1005-0264.2026.008.008
清木丹颗粒联合富马酸丙酚替诺福韦治疗慢性乙型肝炎湿热内蕴证的临床疗效观察
The efficacy of Qingmu Dan granules combined with tenofovir alafenamide fumarate on the chronic hepatitis B patients with syndrome of accumulated dampness-heat
摘要
Abstract
Objective:Based on the"host-guest interaction"theory,exploring the therapeutic effect of Qingmu Dan Granules combined with tenofovir alafenamide fumarate(TAF)on the chronic hepatitis B(CHB)patients with the syndrome of accumulated dampness-heatand its effect on liver fibrosis.Methods:84 CHB patients with the syndrome of accumulated dampness-heat admitted to our hospital from September 2022 to September 2024 were randomly divided into an observation group and a control group,with 42 patients in each group,using a random number table method.The control group received TAF antiviral therapy for 24 weeks,while the observation group received the same treatment as the control group and additionally received Qingmu Dan granules in combination for 24 weeks.During the research process,2 patients fell out of each group,and a total of 80 patients completed the study,with 40 patients in each group.Compare the overall effectiveness of treatment,traditional Chinese medicine(TCM)syndrome scores,liver function,liver fibrosis indicators,serum inflammation indicators,and incidence of adverse reactions between two groups of patients.Results:The total effective rate of the observation group was higher than that of the control group,and the TCM syndrome score after treatment of the observation group was significantly lower than that of the control group(P＜0.05).The results of repeated measures ANOVA showed that there were significant time effects and inter group interaction effects(P＜0.05)in alanine aminotransferase(ALT),liver stiffness measurement(LSM)value,laminin(LN),typeⅢprocollagen(PCⅢ),tumor necrosis factor-α(TNF-α),and interleukin(IL-6)in both groups.The time effects of aspartate aminotransferase(AST),hyaluronic acid(HA),and type Ⅳ collagen(Ⅳ-C)were significant(all P＜0.05).The existence time and inter group effects of transforming growth factor-β 1(TGF-β1)were both statistically significant(P＜0.05).After 12 or 24 weeks of treatment,the levels of ALT,AST,LSM,LN,PC Ⅲ,Ⅳ-C,TNF-α,TGF-β1,and IL-6 in the observation group were significantly lower than those in the control group(all P＜0.05).After 24 weeks of treatment,the HA level in the observation group were significantly reduced compared to that in the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(12.50％vs 7.50％,P＞0.05).Conclusion:The combination of Qingmu Dan granules and TAF significantly improved the overall treatment efficacy,TCM syndrome scores,liver function and fibrosis parameters,and inhibiting inflammatory reactions in the CHB patients with the syndrome of accumulated dampness-heat,with a favorable safety profile.关键词
清木丹颗粒/富马酸丙酚替诺福韦/慢性乙型肝炎/湿热内蕴证/"主客交"理论Key words
Qingmu Dan granules/tenofovir alafenamide fumarate/chronic hepatitics B/syndrome of accumulated dampness-heat/"host-guest interaction"theory分类
医药卫生引用本文复制引用
宋春荣,南然,刘永刚,黄玉,席奇,常占杰..清木丹颗粒联合富马酸丙酚替诺福韦治疗慢性乙型肝炎湿热内蕴证的临床疗效观察[J].中西医结合肝病杂志,2026,36(8):982-986,5.基金项目
全国名老中医药专家常占杰传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
