中医临床研究2026，Vol.18Issue(17)：11-19,9.DOI:10.3969/j.issn.1674-7860.2026.17.002
基于网络药理学和分子对接探究防风治疗皮肤瘙痒的作用机制
Mechanism of Fangfeng in the treatment of skin pruritus based on network pharmacology and molecular docking
摘要
Abstract
Objective:To explore the mechanism of Fangfeng(Saposhnikoviae Radix)in the treatment of skin pruritus based on network pharmacology and molecular docking.Methods:The active components and targets of Fangfeng were screened by Traditional Chinese Medicine Systems Pharmacology Data Mining Platform(TCMSP)and Traditional Chinese Medicine Integrated Pharmacology Database(TCMID).GeneCards gene database,TTD tumor target database and OMIM gene mutation database were used to screen the targets related to skin pruritus.Venny 2.1 platform was used to obtain the intersection targets of Fangfeng and pruritus.STRING database was used to analyze the correlations among intersection targets.A"drug-active component-intersection targets"network diagram was constructed in Cytoscape 3.9.0 software.GO and KEGG enrichment analysis were performed by DAVID,and molecular docking analysis was conducted between the core active components and core targets of Fangfeng using AutoDockTools 1.5.7 software.Results:Network pharmacological analysis identified 18 active components in Fangfeng,including anomalin,divaricatacid,and divaricatol,among them.A total of 1 098 pruritus-associated targets were collected.After intersecting the targets of Fangfeng's active components with those of pruritus,98 common targets were obtained,with five key targets identified:V-Akt murine thymoma viral oncogene homolog 1(AKT1),epidermal growth factor receptor(EGFR),Janus tyrosine kinase(JAK)2,phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),and phosphoinositide-3-kinase regulatory subunit 1(PIK3R1).KEGG enrichment analysis showed that Fangfeng may treat skin pruritus by regulating the PI3K-Akt signaling pathway,JAK-STAT signaling pathway,and other pathways.Molecular docking results indicated that most of the core components of Fangfeng exhibited binding energies lower than-20.92 kJ/mol with key targets,suggesting favorable docking activity.Conclusion:This study,based on network pharmacology and molecular docking,reveals that Fangfeng treats skin pruritus through a multi-component,multi-target,and multi-pathway approach.These findings provide a theoretical basis for further elucidating the mechanism of Fangfeng in the treatment of skin pruritus.关键词
防风/皮肤瘙痒/网络药理学/分子对接Key words
Fangfeng/Skin pruritus/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
王霄雅,张澜,徐阳,岳显文,罗浩铭,鲍慧玮..基于网络药理学和分子对接探究防风治疗皮肤瘙痒的作用机制[J].中医临床研究,2026,18(17):11-19,9.基金项目
吉林省科技发展计划项目(YDZJ202401503ZYTS). （YDZJ202401503ZYTS）
