中医临床研究2026，Vol.18Issue(17)：42-50,9.DOI:10.3969/j.issn.1674-7860.2026.17.005
基于网络药理学和分子对接技术探讨黄连阿胶汤"异病同治"慢性失眠和围绝经期综合征的作用机制
Exploration of the mechanism of action of Huanglian Ejiao decoction in treating chronic insomnia and peri menopausal syndrome based on network pharmacology and molecular docking
摘要
Abstract
Objective:To explore the pharmacological mechanism of the Huanglian Ejiao decoction(黄连阿胶汤)for chronic insomnia and peripheral menopause syndrome by network pharmacology and molecular docking technology.Methods:The chemical components and target genes of the Huanglian Ejiao decoction were retrieved from BATMAN-TCM,and target genes of diseases were obtained from GeneCards.The intersection of diseases and drugs targets in the Huanglian Ejiao decoction was taken to build the protein-protein interaction network by STRING platform.The intersecting targets were imported into Metascape database for GO function and KEGG pathway enrichment analyses,and finally AutoDuckVina was used to verify the molecular docking between the key active ingredients of the Huanglian Ejiao decoction and the core targets.Results:Through screening,5 key ingredients were identified:quercetin,berberine,vitamin D3,tetrandrine and oleic acid,along with 5 core targets:TP53,STAT3,AKT1,IL-6 and TNF.GO functional enrichment analysis showed 2 706 biological processes,144 cell components and 287 molecular functions.There were 217 KEGG pathways,of which mainly involved pathways in cancer and lipid and atherosclerosis.Conclusion:The Huanglian Ejiao decoction has the effect of"treating different diseases with same method"for chronic insomnia and peripheral menopause syndrome through multiple targets and multiple pathways.关键词
网络药理学/分子对接/黄连阿胶汤/慢性失眠/围绝经期综合征Key words
Network pharmacology/Molecular docking/The Huanglian Ejiao decoction/Chronic insomnia/Peripheral menopause syndrome分类
医药卫生引用本文复制引用
王松,陈静..基于网络药理学和分子对接技术探讨黄连阿胶汤"异病同治"慢性失眠和围绝经期综合征的作用机制[J].中医临床研究,2026,18(17):42-50,9.基金项目
四川省名中医工作室建设项目(川中医药办函[2022]36号). （川中医药办函[2022]36号）
