中医临床研究2026，Vol.18Issue(18)：13-22,10.DOI:10.3969/j.issn.1674-7860.2026.18.002
基于数据挖掘技术分析不育验方与验案的用药规律及潜在机制
Medication rules and mechanisms of empirical prescriptions and cases for treating infertility based on data mining
摘要
Abstract
Objective:This study employs data mining and bioinformatics to analyze the medication rules of empirical prescriptions and cases for treating infertility,and to predict the potential mechanisms of the core herbal combinations.Methods:Prescriptions for infertility were collected from Chinese Medicine Formula Database and CNKI.The Traditional Chinese Medicine Inheritance Support System V3.0 was used to analyze herb frequencies and compatibility rules.Network stability was assessed by comparing topological features before and after target removal to inform clinical grading recommendations.DAVID database was used for GO and KEGG pathway enrichment analysis of the GradeⅠ core prescriptions.Enrichment was also performed on clinical infertility datasets from the GEO database.Results:From 166 historical formulas,three GradeⅠ core prescriptions were identified,characterized by tonifying deficiency as the principal method,supplemented by astringent and interior-warming herbs.From 179 modern journal-documented prescriptions,one Grade Ⅰ core formula was identified,also primarily tonifying deficiency,while incorporating heat-clearing and blood-activating methods.Enriched pathways for GradeⅠ prescriptions,consistent with GEO clinical data,included steroid hormone receptor signaling,mitochondrial ATP binding,and metabolic processes.Conclusion:This study elucidates the medication rules of effective historical and modern prescriptions for infertility.The identified GradeⅠ core formulas and their associated biological pathways provide a reference for clinical prevention,treatment,and novel drug screening for infertility.关键词
数据挖掘/不育/验方/验案/用药规律Key words
Data mining/Infertility/Empirical prescription/Empirical case/Medication rules分类
医药卫生引用本文复制引用
张丰荣,李煜,常梦丽,王欢欢,徐核,张毅,唐仕欢..基于数据挖掘技术分析不育验方与验案的用药规律及潜在机制[J].中医临床研究,2026,18(18):13-22,10.基金项目
中国中医科学院科技创新工程项目(CI2021A03705 （）
CI2023E001TS) （）
国家重点研发计划项目(2018YFC1704101). （2018YFC1704101）
