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A progressive discovery strategy for anti-Alzheimer's drug identification:In vitro screening with an LPS-induced neuroinflammatory cell model and in vivo validation in 5xFAD mice

Junyi Zhou Hongping Hou Xiaolu Wei Haiyu Zhao Linna Wang Lianmei Wang Pengyue Li Yan Zhang Yuheng Wang Yan Rong Lihua Chen Huijun Wang

中医药科学（英文）2026，Vol.4Issue(3)：255-269,15.
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中医药科学（英文）2026，Vol.4Issue(3)：255-269,15.DOI:10.1097/st9.0000000000000100

A progressive discovery strategy for anti-Alzheimer's drug identification:In vitro screening with an LPS-induced neuroinflammatory cell model and in vivo validation in 5xFAD mice

A progressive discovery strategy for anti-Alzheimer's drug identification:In vitro screening with an LPS-induced neuroinflammatory cell model and in vivo validation in 5xFAD mice

Junyi Zhou 1Hongping Hou 1Xiaolu Wei 1Haiyu Zhao 1Linna Wang 2Lianmei Wang 1Pengyue Li 1Yan Zhang 1Yuheng Wang 1Yan Rong 1Lihua Chen 1Huijun Wang1

作者信息

  • 1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China
  • 2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China||China Meheco Great Wall Pharma Co.,Ltd.,Beijing,China
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摘要

关键词

5xFAD mice/AD cell line construction/Alzheimer's disease/Benzoylaconitine/Metabolomics/Neuroinflammation

Key words

5xFAD mice/AD cell line construction/Alzheimer's disease/Benzoylaconitine/Metabolomics/Neuroinflammation

引用本文复制引用

Junyi Zhou,Hongping Hou,Xiaolu Wei,Haiyu Zhao,Linna Wang,Lianmei Wang,Pengyue Li,Yan Zhang,Yuheng Wang,Yan Rong,Lihua Chen,Huijun Wang..A progressive discovery strategy for anti-Alzheimer's drug identification:In vitro screening with an LPS-induced neuroinflammatory cell model and in vivo validation in 5xFAD mice[J].中医药科学（英文）,2026,4(3):255-269,15.

基金项目

This work was supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(Grant Nos.CI2024E003 KC-05,CI2023E001TS09,CI2023C020YL,CI2021A04510),the Beijing Natural Science Foundation(Grant No.7254509),the Fundamental Research Funds for the Central Public Welfare Research Institutes of China(Grant Nos.ZZ15-YQ-032,ZZ17-YQ-015),and the Innovative Team of Traditional Chinese Medicine Toxicology(Grant No.CI2021B016). （Grant Nos.CI2024E003 KC-05,CI2023E001TS09,CI2023C020YL,CI2021A04510）

中医药科学（英文）

2836-922X

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