北京中医药大学学报2026，Vol.49Issue(9)：1292-1298,7.DOI:10.3969/j.issn.1006-2157.2026.09.013
从顽痰伏络论治耐药铜绿假单胞菌所致肺部感染
Treating drug-resistant Pseudomonas aeruginosa-induced pulmonary infection from the perspective of stubborn phlegm lurking in the collaterals
摘要
Abstract
Pulmonary infection caused by drug-resistant Pseudomonas aeruginosa frequently occurs in older patients and in those with chronic airway diseases,recurrent hospitalizations,or repeated prior exposure to antimicrobial agents.It is characterized by difficulty in eradicating the pathogen,a protracted clinical course,recurrent acute exacerbations,and persistent respiratory symptoms even after infection control.Based on the traditional Chinese medicine(TCM)theories concerning phlegm,latent pathogens,and collateral diseases,this paper proposes a therapeutic approach for pulmonary infection induced by drug-resistant Pseudomonas aeruginosa from the perspective of stubborn phlegm lurking in lung collaterals.Deficiency of the body's vital resistance is considered as the pathogenic basis,whereas lung invasion by heat toxin and body fluid consumption with subsequent phlegm formation constitute the initial pathogenic process.As phlegm turbidity persists,it gradually develops into stubborn phlegm,which interacts with heat toxin and blood stasis and becomes deeply lodged in the pulmonary collaterals.This result in the persistence of pathogenic factors and their reactivation under triggering conditions.Thus,the pathogenesis is characterized by the coexistence of vital resistance deficiency and pathogenic excess,the intermingling of heat toxin and phlegm turbidity,and the progressive aggravation of stubborn phlegm retention,latent pathogenic factors in the collaterals,and phlegm-blood stasis binding.Treatment should strengthen the body's vital resistance,eliminate pathogenic factors,resolve phlegm,unblock the collaterals,and follow stage-based management.The acute exacerbation and protracted and recurrent stages are treated with modified Fuzheng Jiedu Huayu Formula as the basic prescription.During acute exacerbations,emphasis is placed on clearing heat and detoxifying,resolving phlegm and discharging pus,with concurrent support for the body's vital resistance.During the protracted or recurrent stage,treatment focuses on clearing heat,resolving phlegm,softening hardness,unblocking the collaterals,and eliminating residual toxins.During recovery,Jiexing Junzi Granules are used to replenish qi and nourish yin,regulate and tonify the spleen and lung,and resolve residual phlegm.This therapeutic framework provides a reference for the TCM management of pulmonary infection caused by drug-resistant Pseudomonas aeruginosa.关键词
耐药铜绿假单胞菌/肺部感染/顽痰伏络/分期论治/化痰通络Key words
drug-resistant Pseudomonas aeruginosa/pulmonary infection/stubborn phlegm lurking in the collaterals/stage-based treatment/resolving phlegm and unblocking the collaterals分类
医药卫生引用本文复制引用
王禹霖,于会勇,王毅,满天,胡明凯,崔泰宁,王成祥..从顽痰伏络论治耐药铜绿假单胞菌所致肺部感染[J].北京中医药大学学报,2026,49(9):1292-1298,7.基金项目
首都卫生发展科研专项(No.2022-2-7034) （No.2022-2-7034）
中华中医药学会联合攻关项目2025 年度优势病种专项(No.NCIM25-2) Capital Health Development Research Project(No.2022-2-7034) （No.NCIM25-2）
