北京中医药大学学报2026，Vol.49Issue(9)：1299-1303,5.DOI:10.3969/j.issn.1006-2157.2026.09.014
基于中医"膏肓"理论探讨射血分数保留的心力衰竭心脏外膜脂肪组织的形成与防治思路
Formation and prevention strategies of epicardial adipose tissue in heart failure with preserved ejection fraction based on"Gao Huang"theory of traditional Chinese medicine
摘要
Abstract
Heart failure with preserved ejection fraction(HFpEF)lacks effective treatments.Abnormal accumulation and inflammatory activation of epicardial adipose tissue(EAT)play a pivotal role in disease progression.This paper proposes a hypothesis that the traditional Chinese medicine(TCM)concept of"Gao Huang"is highly correlated with EAT."Gao Huang"is a deep space below the heart and above the diaphragm.EAT lies in the sub epicardial space between the myocardium and the visceral pericardium.The two are adjacent anatomical regions related to the pericardium.Lipids serve as their core material basis("Gao"as adipose tissue),and both possess the potential to transform from a physiological energy reserve that protects the heart from a pathological source of inflammation that damages the heart.The pathological accumulation of EAT can be regarded as a TCM process in which dysfunctional lipid metabolism leads to directional deposition in the"Gao-Huang"area via the sanjiao and pericardium meridians,with the core pathogenesis being dysfunction of sanjiao qi transformation.Based on this,this paper proposes a prevention and treatment principle of"regulating the triple energizer and eliminating Gao to prevent progression",emphasizing early intervention,combining external therapies such as acupuncture and plaster massage to directly target the lesion,along with lifestyle modifications.This strategy of holistic regulation combined with local intervention provides a new path for integrated TCM and Western medicine diagnosis and treatment of HFpEF and offers a reference for using classic TCM theories to interpret mechanisms of complex modern diseases.关键词
射血分数保留的心力衰竭/心脏外膜脂肪组织/膏肓/三焦气化Key words
heart failure with preserved ejection fraction/epicardial adipose tissue/Gao Huang/sanjiao qi transformation分类
医药卫生引用本文复制引用
牟芸莹,刘思雨,魏玥,梁小雨,陈姿伊,曹湛涛,董国菊..基于中医"膏肓"理论探讨射血分数保留的心力衰竭心脏外膜脂肪组织的形成与防治思路[J].北京中医药大学学报,2026,49(9):1299-1303,5.基金项目
国家自然科学基金项目(No.82574852) （No.82574852）
中国中医科学院西苑医院提升中医药临床循证证据级别研究专项(No.XYZX0201-02) National Natural Science Foundation of China(No.82574852) （No.XYZX0201-02）
