摘要
Abstract
Objective:To investigate the pathogen composition and antimicrobial resistance characteristics of postoperative acute infectious endophthalmitis in ophthalmology,and provide evidence for clinical antimicrobial therapy.Methods:We retrospectively analyzed the clinical data of 17 patients with culture-positive postoperative acute infectious endophthalmitis.These patients were admitted to an ophthalmic hospital group between January 2024 to June 2025.The data included pathogen distribution,antimicrobial susceptibility test results,treatment regimens,and clinical outcomes.Results:We isolated 17 pathogens,Gram-positive bacteria accounted for 94.1%(16/17).Staphylococcus epidermidis was the most common pathogen,at 52.9%(9/17).Among the 9 S.epidermidis isolates,methicillin-resistant Staphylococcus epidermidis(MRSE)made up 55.6%(5/9).Antibiotic susceptibility testing showed that MRSE was completely resistant to levofloxacin and ciprofloxacin(0%susceptibility rate).It was completely susceptible to vancomycin and rifampicin(100%susceptibility rate).And it had an 80%susceptibility rate to tetracycline and gentamicin.All patients received combined antimicrobial therapy.This included topical application(17 cases,100%),vitreous cavity injection(15 cases,88.2%),and systemic administration(17 cases,100%).The antimicrobial susceptibility matching rates were 58.8%,100%,and 94.1%,respectively.In the end,88.2%(15/17)of patients achieved stable conditions,while 11.8%(2/17)were transferred to other hospitals.Conclusions:Gram-positive bacteria are the main pathogens in postoperative acute infectious endophthalmitis.Staphylococcus epidermidis is the most prevalent.The detection rate of MRSE is high,and there is widespread resistance to fluoroquinolones.We recommend empirical treatment with vancomycin combined with cefotaxime intravitreal injection.And we should adjust it in time based on antimicrobial susceptibility results.At the same time,it is essential to strengthen perioperative infection control measures.关键词
急性感染性眼内炎/病原菌分布/耐药性/抗菌药物Key words
acute infectious endophthalmitis/pathogen distribution/drug resistance/antimicrobial agents分类
医药卫生
