中国药理学通报2026，Vol.42Issue(10)：1827-1832,6.DOI:10.12360/CPB202601020
铁死亡序贯轴在动脉粥样硬化中的致病机制与中药复方干预策略研究进展
Research progress on pathogenic mechanism of ferroptosis sequential axis in atherosclerosis and its intervention strategies with herbal formulations
摘要
Abstract
Ferroptosis is an iron-dependent,lipid peroxidation-driven form of programmed cell death that is closely associated with atherosclerosis.Its mechanisms involve lipid metabolic dis-orders,iron imbalance,and impaired antioxidant systems.In atherosclerosis,ferroptosis in endothelial cells serves as the ini-tiating event,ferroptosis in macrophages/foam cells promotes plaque progression,and ferroptosis in smooth muscle cells weakens plaque stability.This article also summarizes recent advances in the regulation of ferroptosis by traditional Chinese medicine formulas against atherosclerosis,offering new perspec-tives for mechanistic studies and drug development.关键词
铁死亡/脂质过氧化/铁过载/中药复方/动脉粥样硬化/研究进展Key words
ferroptosis/lipid peroxidation/iron overload/herbal formula/atherosclerosis/research progress分类
医药卫生引用本文复制引用
郭鹤,孟宪生,陈志超,刘顺宇,张欢,张颖,杨莺,郑一..铁死亡序贯轴在动脉粥样硬化中的致病机制与中药复方干预策略研究进展[J].中国药理学通报,2026,42(10):1827-1832,6.基金项目
国家自然科学基金青年项目(No 82505220) （No 82505220）
辽宁省科技计划联合计划重点研发项目(No 2025JH2/101800263) （No 2025JH2/101800263）
辽宁省科技计划联合计划自然科学基金面上项目(No 2025-MSLH-483) （No 2025-MSLH-483）
辽宁省教育厅自主选题项目(No LJ212410162016) （No LJ212410162016）
