中国药理学通报2026，Vol.42Issue(10)：1833-1838,6.DOI:10.12360/CPB202604011
基于Hippo信号通路探讨中医药治疗肝纤维化的研究进展
Research progress on traditional Chinese medicine in treating liver fibrosis based on Hippo signaling pathway
摘要
Abstract
Hepatic fibrosis is a critical pathological stage in the progression of many chronic liver diseases toward cirrhosis and even hepatocellular carcinoma.The Hippo signaling pathway is an evolutionarily highly conserved signal transduction pathway.Dysregulation of the Hippo signaling pathway is associated with key processes in hepatic fibrosis,including HSC activation,ECM deposition,and cell apoptosis and senescence.Many ac-tive ingredients and formulas of traditional Chinese medicine(TCM)have been shown to delay or even reverse the progres-sion of hepatic fibrosis by regulating the expression of key mol-ecules in the Hippo signaling pathway,inhibiting HSC activa-tion,modulating HSC apoptosis and senescence,reducing ECM deposition,influencing macrophage polarization,and crosstalking with critical pathways such as TGF-β/Smad,Hedge hog,and AMPK.This article aims to summarize the mecha-nisms of the Hippo signaling pathway in hepatic fibrosis and sys-tematically review the latest research on TCM interventions tar-geting this pathway,thereby providing new reference for the TCM treatment of hepatic fibrosis.关键词
Hippo信号通路/中医药/肝纤维化/肝星状细胞/YAP/TAZ/中药活性成分Key words
Hippo signaling pathway/Chinese traditional medicine/liver fibrosis/hepatic stellate cells/YAP/TAZ/ac-tive ingredients of Chinese medicine分类
医药卫生引用本文复制引用
郭欣,宋鹏,李红梅,张娟,徐冰蕊,刘俊宏..基于Hippo信号通路探讨中医药治疗肝纤维化的研究进展[J].中国药理学通报,2026,42(10):1833-1838,6.基金项目
国家中医药管理局青年岐黄学者基金项目(国中医药人教函[2022]256号) （国中医药人教函[2022]256号）
甘肃省科学技术厅创新基地和人才计划项目(21JR7RA682) （21JR7RA682）
