大学化学2026，Vol.41Issue(9)：282-292,11.DOI:10.12461/PKU.DXHX202508051
姜黄素/铜胶体粒子的构建与控释性能分析
Synthesis and controlled release analysis of curcumin/copper colloidal nanoparticles:an innovative physical chemistry experiment for medical undergraduates
摘要
Abstract
To improve pharmacy undergraduates'understanding and application of colloid chemistry and chemical kinetics while addressing the lack of innovation and engagement in traditional physical chemistry experiments,we developed a teaching experiment involving the preparation of curcumin/copper colloidal nanoparticles and their drug release kinetics.This experiment combines scientific education with ideological elements to enhance students'ability to integrate theoretical knowledge with practical skills.Using coordination bonding and self-assembly techniques,we synthesized well-dispersed drug/metal colloidal nanoparticles with uniform particle sizes.The nanoparticles were characterized by transmission electron microscopy,dynamic light scattering,and UV-Vis spectrophotometry to determine their size distribution,surface charge,UV-Vis absorption peaks,pH-dependent controlled release properties,and free radical generation capacity.This open-ended experimental design not only strengthens student'ability to connect theory with practice but also stimulates their interest through interdisciplinary research,effectively bridging fundamental teaching with scientific training to cultivate innovative pharmaceutical professionals.关键词
胶体粒子/姜黄素/药物释放/化学动力学方程Key words
Colloidal nanoparticles/Curcumin/Drug release/Chemical kinetics equation分类
社会科学引用本文复制引用
纪禹行,吴爱芝,邬泉周,赵小军..姜黄素/铜胶体粒子的构建与控释性能分析[J].大学化学,2026,41(9):282-292,11.基金项目
国家自然科学基金(22002020) （22002020）
