分析化学2026，Vol.54Issue(9)：1505-1516,中插7-中插8,14.DOI:10.19756/j.issn.0253-3820.261227
纳米材料在深度血浆蛋白质组学中的应用进展
Application Progress of Nanomaterials in Deep Plasma Proteomics
摘要
Abstract
Plasma proteomics is an important technical tool for systematically characterizing physiological and pathological changes in the body,and it has demonstrated significant practical value in areas such as early disease diagnosis and pathological research.However,due to the complex composition of plasma proteins and the extremely wide dynamic range of protein abundance,the depth of plasma proteomics identification based on mass spectrometry technology is significantly limited.Currently,pretreatment strategies using nanomaterials to enrich low-abundance proteins in plasma have significantly enhanced the depth of identification in plasma proteomics,demonstrating considerable value for both clinical and research applications.This article provided a review of the mechanisms of action,typical material systems,and applications of nanomaterial-based enrichment of low-abundance proteins in plasma proteomics.It further explored the challenges facing this enrichment method and future directions for its development,offering guidance for establishing a highly efficient and accurate platform for in-depth plasma proteomics analysis and advancing its applications in elucidating disease mechanisms,discovering biomarkers,and advancing precision medicine.关键词
质谱/蛋白质组学/纳米材料/血浆/低丰度蛋白质/评述Key words
Mass spectrometry/Proteomics/Nanomaterials/Plasma/Low-abundance proteins/Review引用本文复制引用
段云霞,王梦颖,赵瑶瑶,窦相南,郭广生,汪夏燕..纳米材料在深度血浆蛋白质组学中的应用进展[J].分析化学,2026,54(9):1505-1516,中插7-中插8,14.基金项目
国家自然科学基金项目(Nos.22127805,22574007,22306007)资助. Supported by the National Natural Science Foundation of China(Nos.22127805,22574007,22306007). （Nos.22127805,22574007,22306007）
