分析化学2026，Vol.54Issue(9)：1575-1587,中插23-中插26,17.DOI:10.19756/j.issn.0253-3820.261200
双金属协同增强Fe/Cu-MOF纳米酶的构建及其对四环素和苯酚的高灵敏检测
Synergistically Enhanced Bimetallic Fe/Cu-MOF Nanozyme for Highly Sensitive Detection of Tetracycline and Phenol
摘要
Abstract
Designing and synthesizing bimetallic nanozymes with multiple enzyme-mimicking activities is a key research focus in the field of environmental analysis.In this study,a heterogeneous bimetallic Fe/Cu metal-organic framework(MOF)nanozyme with excellent oxidase(OXD)-like and laccase-like dual catalytic activities was successfully constructed via a one-pot self-assembly of Fe3+and Cu2+with 4,4′-biphenyldicarboxylic acid(4,4′-BPDC).Mechanistic studies demonstrated that the synergistic interaction between Fe and Cu active sites within the MOF framework effectively improved electron-transfer efficiency and substrate affinity.Moreover,the dual redox cycles of Fe3+/Fe2+and Cu2+/Cu+effectively promoted the in situ generation of reactive oxygen species(ROS),particularly superoxide anion radicals(·O2–).Based on these remarkable properties,an efficient detection platform for environmental pollutants was developed,enabling highly sensitive and selective detection of tetracycline(TC)and phenol under neutral conditions,with limits of detection(LODs)as low as 1.25 μmol/L and 2.51 μmol/L,respectively.In spiked recovery experiments in real water samples,the proposed system achieved recoveries ranging from 94.1％to 103.0％,with relative standard deviations(RSDs)of less than 5％.This study not only provided new insights into the rational design of heterogeneous bimetallic MOF nanozymes but also offered a feasible analytical strategy for the on-site detection of pollutants and water quality assessment in complex environmental water bodies.关键词
双金属有机框架/类氧化酶活性/类漆酶活性/苯酚/四环素/检测Key words
Bimetallic metal-organic framework/Oxidase-like activity/Laccase-like activity/Phenol/Tetracycline/Detection引用本文复制引用
谭君坪,胡聪意,黄承志,黄京韬..双金属协同增强Fe/Cu-MOF纳米酶的构建及其对四环素和苯酚的高灵敏检测[J].分析化学,2026,54(9):1575-1587,中插23-中插26,17.基金项目
国家自然科学基金项目(No.22134005)、重庆市杰出科学家人才计划项目(No.cstc 2021 ycjh-bgzxm 0179)和中央高校基本科研业务费科研启动项目(No.SWU-KQ25007)资助. Supported by the National Natural Science Foundation of China(No.22134005),the Chongqing Talents Program for Outstanding Scientists(No.cstc 2021 ycjh-bgzxm 0179)and the Fundamental Research Funds for the Central Universities(No.SWU-KQ25007). （No.22134005）
