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Machine learning-driven discovery of therapeutic nucleoside hydrogels for periodontitis

Weiqi Li Yinghui Wen Zhenyuan Huang Fangyuan Shuai Yijia Yin Qianming Chen Fudong Zhu Hao Xu Hang Zhao

国际口腔科学杂志（英文版）2026，Vol.18Issue(4)：635-649,15.

国际口腔科学杂志（英文版）2026，Vol.18Issue(4)：635-649,15.DOI:10.1038/s41368-026-00438-3

Machine learning-driven discovery of therapeutic nucleoside hydrogels for periodontitis

Weiqi Li ¹Yinghui Wen ²Zhenyuan Huang ²Fangyuan Shuai ²Yijia Yin ²Qianming Chen ²Fudong Zhu ³Hao Xu ²Hang Zhao²

作者信息

1. State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Research Unit of Oral Carcinogenesis and Management&Chinese Academy of Medical Sciences,West China Hospital of Stomatology,Sichuan University,Chengdu,China||Department of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,China
2. State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Research Unit of Oral Carcinogenesis and Management&Chinese Academy of Medical Sciences,West China Hospital of Stomatology,Sichuan University,Chengdu,China
3. Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou,China
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Weiqi Li,Yinghui Wen,Zhenyuan Huang,Fangyuan Shuai,Yijia Yin,Qianming Chen,Fudong Zhu,Hao Xu,Hang Zhao..Machine learning-driven discovery of therapeutic nucleoside hydrogels for periodontitis[J].国际口腔科学杂志（英文版）,2026,18(4):635-649,15.

基金项目

National Key R&D Program of China(No.2022YFC2402901 to H.Z.) （No.2022YFC2402901 to H.Z.）

National Natural Science Foundations of China(No.82571160 to H.Z.and No.82370962 to H.X.) （No.82571160 to H.Z.and No.82370962 to H.X.）

Central Government Guided Local Science and Technology Development Fund Projects(No.2024ZYD0176 to H.Z.) （No.2024ZYD0176 to H.Z.）

Research Funding from State Key Laboratory of Oral Diseases,West China School/Hospital of Stomatology Sichuan University(No.RCDWJS2026-14,SKLOD-2025KP001,SKLOD-R011 to H.Z.) （No.RCDWJS2026-14,SKLOD-2025KP001,SKLOD-R011 to H.Z.）

The Natural Science Foundation of Sichuan Province of China(No.2026NSFSC1587 to W.L.and 2026NSFSC0489 to H.X.) （No.2026NSFSC1587 to W.L.and 2026NSFSC0489 to H.X.）

China Postdoctoral Science Foundation(CPSF,No.2025M781704 to W.L.),the Postdoctoral Fellowship Program of CPSF(No.GZB20250442 to W.L.).The authors thank Kaichao Wang and Lideng Cao(State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University)for helping us perform studies.The authors also thank Siyuan Hao for helping with data collation. （CPSF,No.2025M781704 to W.L.）

国际口腔科学杂志（英文版）

ISSN：1674-2818

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