物理化学学报2026，Vol.42Issue(10)：136-150,15.DOI:10.1016/j.actphy.2026.100265
透明亲水的"凤凰衣"用作角膜修复材料
Transparent and hydrophilic"phoenix garment"for corneal stromal regeneration
摘要
Abstract
Globally,irreversible blindness caused by corneal scarring,stromal defects,and trauma continues to rise.Shortages of donor corneas,the high cost of amniotic membrane and collagen patches,and complex ethical oversight have made the development of an abundant,low-cost,and scalable alternative a pressing clinical need.Herein,an"alkaline-transparency"protocol was developed to render"phoenix garment"(chicken eggshell membrane,ESM),transparent,hydrophilicity,and high saturated water content,while preserving its flexibility and suture compatibility.The membrane gradually degraded in the physiological environment,adapting to the pace of tissue repair.In a rabbit anterior-lamellar defect model,the patch rapidly integrated with host stroma,achieving complete re-epithelialization within one week and restoring a smooth,transparent corneal surface within eight weeks,with neatly aligned collagen and no scar formation,indicating effective suppression of myofibroblast activation and reliable restoration of the epithelial barrier.ESM is abundantly available,easy to prepare,and storable at room temperature,offering a safe,economical,and clinically translatable strategy for corneal stromal replacement.关键词
凤凰衣/蛋壳膜/碱处理/角膜再生/生物材料Key words
Phoenix garment/Eggshell membrane/Alkaline treatment/Corneal regeneration/Biomaterials分类
化学化工引用本文复制引用
李翊萌,杨元元,王征科..透明亲水的"凤凰衣"用作角膜修复材料[J].物理化学学报,2026,42(10):136-150,15.基金项目
本研究得到浙江大学启真创新概念验证中心研究项目(GNYZ-2024010) （GNYZ-2024010）
国家重点研发计划项目(2018YFC1004803) （2018YFC1004803）
国家自然科学基金项目(51873187)及浙江省杰出青年科学基金项目(LR20E030004)的资助. （51873187）
