中国医学创新2026，Vol.23Issue(25)：1-6,6.DOI:10.3969/j.issn.1674-4985.2026.25.001
清肺培本汤治疗重型颅脑损伤合并胃肠功能障碍的临床效果
Clinical Efficacy of Qingfei Peiben Decoction in the Treatment of Severe Traumatic Brain Injury Combined with Gastrointestinal Dysfunction
摘要
Abstract
Objective:To explore the clinical effect of Qingfei Peiben Decoction in the treatment of severe traumatic brain injury(sTBI)combined with gastrointestinal dysfunction,and to observe its influence on the patients'consciousness state,inflammatory response and complications.Method:A total of 82 patients with sTBI combined with gastrointestinal dysfunction who were admitted to Changsha Hospital of Traditional Chinese Medicine from January 2024 to December 2025 were selected and divided into the observation group and the control group by random number table method,with 41 cases in each group.The control group was given conventional comprehensive treatment by western medicine,while the observation group was treated with Qingfei Peiben Decoction on the basis of the control group.The treatment courses of both groups were 15 days.The clinical efficacy,gastrointestinal function indicators[intra-abdominal pressure(IAP),gastrointestinal failure(GIF)score],Glasgow coma scale(GCS)score,inflammatory indicators(WBC,CRP,IL-6),and incidence of complications between the two groups were compared.Result:After treatment,the total clinical effective rate of the observation group reached 92.68%,significantly higher than 75.61% of the control group(P<0.05).After 7 days of treatment,the IAP level in the observation group was lower than that in the control group(P<0.05).After 5 and 15 days of treatment,the GIF scores of the observation group were lower than those of the control group(P<0.05).After 15 days of treatment,the GCS score of the observation group was higher than that of the control group(P<0.05).After 5 and 15 days of treatment,the levels of serum WBC,CRP and IL-6 in the observation group were all lower than those in the control group(P<0.05).The total incidence of complications in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:Qingfei Peiben Decoction can effectively promote the recovery of gastrointestinal function in patients with sTBI combined with gastrointestinal dysfunction,improve their state of consciousness,reduce the inflammatory response of the body,lower the incidence of complications,and enhance clinical efficacy.关键词
清肺培本汤/重型颅脑损伤/胃肠功能/炎症指标Key words
Qingfei Peiben Decoction/Severe traumatic brain injury/Gastrointestinal function/Inflammatory indicators分类
医药卫生引用本文复制引用
曾玉,段继新,罗凯,李中丽..清肺培本汤治疗重型颅脑损伤合并胃肠功能障碍的临床效果[J].中国医学创新,2026,23(25):1-6,6.基金项目
长沙市2024年度第二批指导性科技计划项目(kzd2402004) （kzd2402004）
