食品科学2006，Vol.27Issue(1)：223-226,4.
香菇多糖L-2对荷瘤小鼠TNF-α和IL-2的影响
Effect of Polysaccharide L-2 from Lentinus edodes on TNF- α and IL-2
摘要
Abstract
The effects of the polysaccharide (L-2) extracted from Lentinus edodes on the immune response of Sarcoma 180-bearing mice were evaluated. Mice were treated with two doses of polysaccharide L-2 ( 1, 10mg/kg body weight) for 10 days. The concentration of tumor necrosis factor-alpha (TNF- α ), interferon-2 (IL-2) in mice serum and TNF- α mRNA expression were determined. The concentration of TNF- α in serum increased significantly in two doses groups compared to the model control group, but IL-2 not. The level of TNF- α mRNA transcription increased significantly in two doses groups to the model control group. Results of these studies demonstrated the polysaccharide L-2 significantly promoted TNF- α production, immunity potentiating and anti-tumor effects of the polysaccharide L-2 were associated with its potentiation of TNF- α mRNA expression at the transcriptional level.关键词
香菇/多糖/肿瘤坏死因子/白介素2Key words
Lentinus edodes/polysaccharide/rumor necrosis factor-alpha/interferon-2分类
医药卫生引用本文复制引用
阮征,付晓芳,周泉城,胡筱波,吴谋成..香菇多糖L-2对荷瘤小鼠TNF-α和IL-2的影响[J].食品科学,2006,27(1):223-226,4.基金项目
湖北省"十五"科技重点攻关项目(2001AA204A03) （2001AA204A03）
