P38丝裂原活化蛋白激酶在炎症因子诱导糖尿病肾病中的作用 OACSTPCD
Role of p38 mitogen-activated protein kinase in inflammatory cytokinesinduced diabetic nephropathy
近年来的研究发现,丝裂原活化蛋白激酶(mitogen-activated protein kinase, MAPK)是细胞将信号从细胞膜传递到细胞核的主要通路.其中p38MAPK可通过调节转化生长因子β1、核因子-κB及血管内皮生长因子等炎症因子的表达影响糖尿病肾病的进程.研究p38MAPK及其信号转导通路机制可能为糖尿病肾病的治疗提供新的理论基础,也可为临床提供新的更为有效的诊治手段.
Recent studies have demonstrated that mitogen-activated protein kinase (MAPK) is the major pathway to induce cellular signals from the cell membrane to the nucleus, p38MAPK can affect the process of diabetic nephropathy by regulating the levels of inflammatory cytokines such as transforming growth factor β31, nuclear factor-KB, and vascular endothelial growth factor. Elucidating the mechanism of p38MAPK-mediated signal transduction not only can provide novel…查看全部>>
张苏皖
安徽医科大学附属省立医院内分泌科,合肥,230001
p38丝裂原活化蛋白激酶糖尿病肾病炎症因子
p38 mitogen-activated protein kinase diabetic nephropathy inflammatory cytokines
《国际病理科学与临床杂志》 2011 (1)
73-77,5
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