现代食品科技2011，Vol.27Issue(1)：109-113,5.
液相色谱-串联质谱结合谱库检索测定猪组织中13种氟喹诺酮类药物
Determination of Fluoroquinolones in Pig Tissues by LC-MS/MS Combining with Spectral Library Search
摘要
Abstract
MRM→IDA→EPI→spectral library search model was used to establish a HPLC-electrospray ionization tandem mass spectrometry method for the multi-residue detection of fluoroquinolones in pig tissues. The quantitative and qualitative analysis of the target analyses were achieved by LC-MS/MS combining with spectral library search function. Tissue samples were extracted with N,N-Dimethylformamide and acetonitrile, purified with Waters HLB column, The analytical method in the present study was well validated and good results were obtained with respect to precision, repeatability and spiked recovery. The limit of detection of residues was 0.1～0.5μg/kg for fluoroquinolones, and with a linear range from 1.0 to 5000μg/kg. The mean recovery was of 81.6％～114％ and RSD was of 1.1％～11.2％.关键词
氟喹诺酮/猪组织/液相色谱串联-质谱/谱库引用本文复制引用
蔡勤仁,冯家望,张毅,彭玉芬,薛良辰,余以刚..液相色谱-串联质谱结合谱库检索测定猪组织中13种氟喹诺酮类药物[J].现代食品科技,2011,27(1):109-113,5.基金项目
珠海市科技计划项目(PC20081001) （PC20081001）
