中国食品学报2011，Vol.11Issue(2)：158-162,5.
蛋白质工程在提高蛋白质稳定性中的应用
The Application of Protein Engineering in Improving Protein Stability
赵黎明1
作者信息
- 1. 生物反应器工程国家重点实验室,华东理工大学生物工程学院食品科学与工程系,上海,200237
- 折叠
摘要
Abstract
During the past 18 years there has been a continuous flow of reports describing proteins stabilized by the introduction of mutations. These reports span a period from pioneering rational design work on small enzymes such as T4 lysozyme and barnase to present protein design and directed evolution technique. This literature plays emphasis on introducing the paths to improve protein stability, and the advances of researches in enhance the stability of protein especially of the enzyme, by rational design method, DNA shuffling, combinational design and data-driven design methods.关键词
蛋白质工程/蛋白质稳定性/理性设计/高通量筛选/组合设计Key words
protein engineering/ protein stability/ rational design/ high-throughput screening/ combinational design引用本文复制引用
赵黎明..蛋白质工程在提高蛋白质稳定性中的应用[J].中国食品学报,2011,11(2):158-162,5.
