食品与发酵工业2009，Vol.35Issue(10)：23-27,5.
拟无枝酸菌ST2710转化洛伐他汀为无锡他汀的初步研究
The Studying of Transformation Process in Amycolatopsis sp.Cell Converting Lovastatin into Wuxistatin
摘要
Abstract
Wuxistatin is a novel inhibitor of 3-hydroxy-3-methylglutary(HMG-CoA) reductase which is the ratelimiting enzyme in the process of cholesterol synthesis. Its inhibitory effect of the reductase is four times more efficient than that of Lovastatin, thus it is a new potential drug for reducing the level of cholesterol. With the production of wuxistatin, according to our research, there is another compound named biotransformating product I . Through NMR and LC-MS analysis, molecular structure of biotransformating product I is 2-methyl-, 1,2 ,3 ,7 ,8 ,8a- hexahydro-3-(hydroxymethyl) -7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl) ethy] -1 -naphthalenyl ester. Bio trans-formating product I and wuxistatin are isomers. In addition, the formation of product 1 will influence the formation and existence of wuxistain to some extent, which provides theoretical basis for increasing the production of wuxistatin.关键词
无锡他汀/核磁共振/液质联用/同分异构体Key words
Wuxistatin/NMR/LC-MS/isomers分类
轻工纺织引用本文复制引用
付维来,诸葛斌,于海,方慧英,诸葛健..拟无枝酸菌ST2710转化洛伐他汀为无锡他汀的初步研究[J].食品与发酵工业,2009,35(10):23-27,5.基金项目
江南大学自然预研基金资助(2008LYY017) （2008LYY017）
