现代食品科技2011，Vol.27Issue(7)：780-782,866,4.
枯草芽孢杆菌ATCC6633催化7-苯乙酰胺基-3-Z-丙烯基-3-头孢菌素-4-对甲氧基苄酯的水解
Bacillus Subtilis ATCC6633 Catalyzed Hydrolysis ofp-Methoxybenzyl Protecting Group from p-Methoxybenzyl 7-Phenylacethylamino-3-propenyl-3-cephem-4-carboxylate
摘要
Abstract
Bacillus subtilis ATCC6633 was used to catalyze the de-protection of cis-p- methoxybenzyl-7- phenylacethylamino-3- propenyl-3-cephem-4-carboxylate (cis-GPRE), an intermediate of Cefprozil, to produce cis-7-phenylacetamido-3-propenyl-cephalosporanic acid (cis-GPRA).The yield reached 63％ after optimization. In addition, lipase Novozyme 435 and Amino PS IM showed little activities towardy this reaction.关键词
头孢丙烯/顺式7-苯乙酰胺基-3-2-丙烯基-3-Z-头孢菌素-4-对甲氧基乙醇酯(顺式GPRE)/顺式7-苯乙酰胺基-3-2-丙烯基-3-头孢菌素-4/酸(顺式GPRA)/枯草芽孢杆菌ATCC6633Key words
cefprizol, cis-p-methoxybenzyl-7-phenylacethylamino-3-propenyl-3-cephem-4-carboxylate (cis-GPRE)/ cis-7-phenylacetamido -3- ropenyl-cephalosporanic acid (cis-GPRA)/ Bacillus subtilis ATCC6633引用本文复制引用
荣佳伟,朱明军,冯胜昔,梁世中..枯草芽孢杆菌ATCC6633催化7-苯乙酰胺基-3-Z-丙烯基-3-头孢菌素-4-对甲氧基苄酯的水解[J].现代食品科技,2011,27(7):780-782,866,4.基金项目
广州市科技计划项目资助(2008A1-E4041) （2008A1-E4041）
