现代食品科技2011，Vol.27Issue(8)：885-886,911,3.
聚乙二醇改性水溶性壳聚糖对蛋白药物的释放作用
PEG Modified Water-soluble Chitosan Nanoparticles for Drug Delivery
王春 1扶雄 2杨连生2
作者信息
- 1. 广东石油化工学院化学与生命科学学院,广东茂名525000
- 2. 华南理工大学轻工与食品学院,广东广州510640
- 折叠
摘要
Abstract
PEG modified WSC nanoparticles were prepared based on ionic gelation and the capability of PEG modified water-soluble chitosan (WSC) was used as carriers to load and delivery drug. As a model protein drug, bovine serum albumin (BSA) was incorporated into the nanoparticles. Physicochemical of characterizations of WSC nanoparticles was determined preliminarily. PEG introduction might decrease loading capability of nanoparticles due to the competition effect between BSA and PEG And in vitro release demonstrated that PEG modification could increase release of loading protein drug but the nanoparticles displayed a good release performance stilL关键词
水溶性壳聚糖/聚乙二醇/纳米粒子/牛血清蛋白/蛋白质释放Key words
water-soluble chitosan (WSC)/PEG/nanoparticle/BSA/protein delivery引用本文复制引用
王春,扶雄,杨连生..聚乙二醇改性水溶性壳聚糖对蛋白药物的释放作用[J].现代食品科技,2011,27(8):885-886,911,3.
