食品科学2011，Vol.32Issue(23)：277-280,4.
姬菇多糖对CCl4所致小鼠急性肝损伤的保护作用
Protective Effect of Polysaccharides from Pleurotus cornucopiae on Carbon Tetrachloride-induced Acute Liver Injury in Mice
摘要
Abstract
Objective： To study the protective effect of polysaccharides from Pleurotus cornucopiae（PCNP） on CCl4-induced acute liver injury in mice.Methods： The mice were randomly divided into normal control group and CCl4-induced acute liver injury model group,bifendate treatment group（positive control,at 150 mg/（kg·d）） and PCNP treatment group（400 mg/（kg·d））.The administration of bifendate and PCNP was performed by gavage once a day for 30 days.After the last administration,the model,bifendate treatment and PCNP treatment groups were intragastrically given 1% CCl4 in salad oil solution at the dosage of 80 mg/kg to induce acute liver injury.At 24 h after the administration of CCl4,all the mice were sacrificed to assay antioxidant activities in the blood and liver.Meanwhile,hepatic histopathological changes were also examined.Results： The contents of MDA in the liver and serum AST,ALT and ALP activities revealed an obvious decrease in the PCNP treatment group when compared to the model group,while the contents of GSH and SOD activity in the liver exhibited an obvious increase.Conclusion： PCNP can improve pathological liver injury distinctly and protect against CCl4-induced acute liver injury in mice.关键词
姬菇多糖/急性肝损伤/抗氧化/血清/四氯化碳Key words
Pleurotus cornucopiae polysaccharides/acute liver injury/antioxidation/serum/CCl4分类
轻工纺织引用本文复制引用
周斌,刘俊,程光宇,郭永月,陶明煊..姬菇多糖对CCl4所致小鼠急性肝损伤的保护作用[J].食品科学,2011,32(23):277-280,4.基金项目
江苏省高校自然科学基础研究项目 （）
