食品科学2011，Vol.32Issue(23)：293-296,4.
肉桂醛对HL-60细胞的生长抑制及诱导凋亡作用研究
Proliferation Inhibitory and Apoptosis-inducing Effects of Cinnamaldehyde on HL-60 Cells
摘要
Abstract
Objective： To determine the proliferation inhibitory and apoptosis-inducing effects of cinnamaldehyde on HL-60 cells.Methods： The proliferation inhibitory effect was evaluated using trypan-blue staining and MTT assay,and the apoptosis-inducing effect using flow cytometry,scanning electron microscope（SEM） and transmission electron microscope（TEM）.Results： Cinnamaldehyde had an oblivious inhibitory effect on the proliferation of HL-60 cells with dependence upon its concentration and treatment time and the LC50,median lethal concentration was 34.87 μg/mL.The rate of apoptosis in HL-60 cells was 32.6 % after being treated with cinnamaldehyde at the dose of 20 μg/mL.for 16 h.Typical apoptotic morphological changes in the cells was observed under fluorescence microscopy,SEM and TEM.Conclusion： cinnamaldehyde cna notably inhibit the proliferation and induce the apoptosis of HL-60 cells.关键词
肉桂醛/HL-60细胞/细胞凋亡Key words
cinnamaldehyde/HL-60 cells/apoptosis分类
农业科技引用本文复制引用
魏练平,罗美,蒋瑾,蒋立科..肉桂醛对HL-60细胞的生长抑制及诱导凋亡作用研究[J].食品科学,2011,32(23):293-296,4.基金项目
国家发改委、农业部中试项目 （）
