食品科学2012，Vol.33Issue(7)：138-141,4.
钝顶螺旋藻提取物对细菌群体感应的抑制作用
Inhibitory Activity of Methanol Extract from Spirulina platensis on Bacterial Quorum Sensing
摘要
Abstract
The inhibitory activity of methanol extract from Spirulina platensis on quorum sensing in the mini-Tn5 mutant Chromobacterium violaceum CV026 was investigated. The violacein and biofilm production in CV026 and Shewanella spp. were also measured. The results indicated that 75% methanol extract from Spirulina platensis not only significantly reduced violacein production and biofilm formation at a concentration of 0.125- 1.000 g/100 mL, but also inhibited violacein production induced by exogenous N-hexanoyl homoserine lactone （10 μmol/L C6-HSL）. The inhibitory rates of methanol extract at the dose of 1.000 g/100 mL on violacein production and biofilrn formation were 87.67% and 77.05%, respectively （P 〈0.05）. The growth of CV026 was not affected by methanol extract at a concentration of 0.125 -1.000 g/100 mL, indicating the reduction of CV026 on violacein was due to HSL-induced quorum sensing but not the inhibitory growth of CV026. In conclusion, methanol extract from Spirulina platensis can significantly inhibit bacterial quorum sensing activity, and can therefore used as an bacterial quorum sensing inhibitor for the storage of fresh and processed food.关键词
钝顶螺旋藻/群体感应抑制剂/N-己酰高丝酰胺内酯（C6-HSL）Key words
Spirulinaplatensis/quorum sensing inhibition/N-hexanoyl homoserine lactone (C6-HSL)分类
轻工纺织引用本文复制引用
曾惠,刘尊英,朱素芹,董士远,赵元晖,曾名湧..钝顶螺旋藻提取物对细菌群体感应的抑制作用[J].食品科学,2012,33(7):138-141,4.基金项目
国家自然科学基金项目（31071613）：山东省科技攻关计划项目 （）
