食品科学2012，Vol.33Issue(8)：54-59,6.
青藤碱-环糊精包合工艺的优化及包合常数测定
Optimization of Preparation Process for Sinomenine-Cylcodextrin Inclusion Complex and Its Inclusion Constant
摘要
Abstract
Objectives： To investigate optimal conditions for inclusion complex formation between sinomenine and cylcodextrins and determine the inclusion constants and release in vitro of inclusion complexes prepared with different cyclodextrins.Methods： One-factor-at-a-time and orthogonal array design methods were employed for the optimization of inclusion complex formation conditions.The inclusion constants of sinomenine complexes with β-cylcodextrin（β-CD）,hydroxypropyl-β-cyclodextrin（HP-β-CD） and γ-cyclodextrin（γ-CD） formed under optimal conditions were determined by the phase solubility method.Moreover,their release in vitro was tested.Results： The optimal conditions for forming sinomenine-cylcodextrins inclusion complexes were 1：1 of sinomenine-to-cylcodextrin molar ratio,50 ℃ of temperature,and 3 h of reaction duration at pH 7.The inclusion constants of sinomenine-β-CD,sinomenine-HP-β-CD and sinomenine-γ-CD formed under these conditions were calculated as 501.1,150.0,600.3 L/mol,respectively.Conclusion： sinomenine and cylcodextrins can form stable inclusion complexes at a molar ratio of 1：1.Various inclusion complexes show remarkable sustained release effect on sinomenine.关键词
青藤碱/环糊精/包合常数/正交试验设计/工艺优化Key words
sinomenine/cylcodextrins/inclusion constant/orthogonal array design/process optimization分类
化学化工引用本文复制引用
朱士龙,李勇,林红卫,段友构..青藤碱-环糊精包合工艺的优化及包合常数测定[J].食品科学,2012,33(8):54-59,6.基金项目
国家自然科学基金面上项目 （）
湖南省自然科学基金项目 （）
湖南省教育厅项目 （）
民族药用植物资源研究与利用湖南省重点实验室开放基金项目 （）
吉首大学研究生校级科研项目 （）
