胆汁酸G-蛋白偶联受体激动剂齐墩果酸对高脂饮食小鼠体内糖脂代谢的影响OACSTPCD
Effect of TGR5 Agonist-Oleanolic Acid on Glucose and Lipid Metabo-lism in High Fat Diet Induced Obesity Mice
目的 观察胆汁酸G-蛋白偶联受体(G protein-coupled receptor for bile acids,TGR5) 激动剂齐墩果酸 (oleanolic acid,OA)对肥胖小鼠体重及糖、脂代谢的影响,探讨齐墩果酸减轻肥胖小鼠体重的机制.方法 建立高脂饮食诱导的肥胖小鼠动物模型,并喂食 OA 进行干预.动态测定体重及第17周后内脏脂肪、肝脏重量,并进行葡萄糖耐量实验(glucose tolerence test,GTT);肝脏组织…查看全部>>
Objective To investigate the effect of the agonist for G protein-coupled receptor of bile acids ( TGR5 ) -Oleanolic acid ( OA) on the weight, glucose and lipid metabolism in high fat induced obesity mice and explore the mechanism of weight loss effect of Oleanolic acid . Methods Obesity mice models were established by high fat diet feeding with or without OA . Body weight at each week and visceral fat mass , liver weight after seventeen-week f…查看全部>>
张闻宇;胡晨;娄桂予
河南省郑州人民医院内分泌科,郑州市,450003第三军医大学学员旅8队,重庆市,400038第三军医大学基础部生物化学与分子生物学教研室,重庆市,400038
医药卫生
高脂饲料胆汁酸G-蛋白偶联受体齐墩果酸脂肪合成
high fat diet TGR5 oleanolic acid lipid synthesis
《医学分子生物学杂志》 2012 (2)
114-118,5
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